Gene Symbol | GUCA1C |
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Entrez Gene | 9626 |
Alt Symbol | GCAP3 |
Species | Human |
Gene Type | protein-coding |
Description | guanylate cyclase activator 1C |
Other Description | GCAP 3|guanylyl cyclase-activating protein 3 |
Swissprots | Q9UNM0 O95843 O95844 |
Accessions | AAD19943 EAW79715 EAW79716 O95843 AB593147 BAJ84081 AF110002 AAD19944 AF110003 AAD19945 AV732101 BC103993 AAI03994 BC103994 AAI03995 C20850 EU832759 ACE87770 GQ129299 ACT64433 XM_005247910 XP_005247967 XM_011513334 XP_011511636 NM_005459 NP_005450 |
Function | Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)- sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure. |
Tissue Specificity | Retina. |
Top Pathways | Olfactory transduction, Phototransduction |
GCAP3 CRISPR/Cas9 KO Plasmid (h) - sc-417137 from Santa Cruz Biotechnology
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GCAP3 HDR Plasmid (h) - sc-417137-HDR from Santa Cruz Biotechnology
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GCAP3 Double Nickase Plasmid (h) - sc-417137-NIC from Santa Cruz Biotechnology
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GCAP3 Double Nickase Plasmid (h2) - sc-417137-NIC-2 from Santa Cruz Biotechnology
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GCAP3 CRISPR Activation Plasmid (h) - sc-417137-ACT from Santa Cruz Biotechnology
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GCAP3 CRISPR Activation Plasmid (h2) - sc-417137-ACT-2 from Santa Cruz Biotechnology
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GCAP3 Lentiviral Activation Particles (h) - sc-417137-LAC from Santa Cruz Biotechnology
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GCAP3 Lentiviral Activation Particles (h2) - sc-417137-LAC-2 from Santa Cruz Biotechnology
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GCAP3 siRNA (h) - sc-75114 from Santa Cruz Biotechnology
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GCAP3 shRNA Plasmid (h) - sc-75114-SH from Santa Cruz Biotechnology
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GCAP3 shRNA (h) Lentiviral Particles - sc-75114-V from Santa Cruz Biotechnology
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GCAP3 RNAi - H00009626-R01 from Novus Biologicals
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MISSION® esiRNA - EHU097301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9795 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9795 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00733 from Sigma-Aldrich
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GUCA1C siRNA (Human) - CRH6406 from Cohesion Biosciences
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GUCA1C - MBS8230990 from MyBioSource
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shRNA set against Human GUCA1C (NM_005459.3) - SHH309294 from Creative biogene
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Human GUCA1C siRNA - orb266908 from Biorbyt
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GUCA1C shRNA Plasmid (Human) - CHH6406 from Cohesion Biosciences
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GUCA1C miRNA 3'UTR clone - MiUTR4H-TG04057 from Creative biogene
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