ABCB4

Gene Symbol ABCB4
Entrez Gene 5244
Alt Symbol ABC21, GBD1, ICP3, MDR2, MDR2/3, MDR3, PFIC-3, PGY3
Species Human
Gene Type protein-coding
Description ATP-binding cassette, sub-family B (MDR/TAP), member 4
Other Description ATP-binding cassette sub-family B member 4|P glycoprotein 3/multiple drug resistance 3|P-glycoprotein 3|P-glycoprotein-3/multiple drug resistance-3|multidrug resistance protein 3|multiple drug resistance 3
Swissprots D6W5P3 A4D1D3 Q14813 A0A2V7 D6W5P4 A4D1D4 A4D1D5 P21439
Accessions AAD05023 ABH04421 ABH04422 ABH04423 ABH04424 ABH04425 ABH04426 ABH04427 ABH04428 ABH04429 ABH04430 ABH04431 ABH04432 ABH04433 ABH04434 ABH04435 ABH04436 ABH04437 ABH04438 ABH04439 ABH04440 ABH04441 ABH04442 ABH04443 ABJ53424 ABM92358 ABW04992 ABW04993 ADR80227 AFO64626 AFO64627 AFO64628 AFO64629 AFO64630 AFO64631 AFO64632 AFO64633 AHA83530 CAA84543 EAL24174 EAL24175 EAL24176 EAW76944 EAW76945 EAW76946 EAW76947 EAW76948 EAW76949 EAW76950 EAW76951 EAW76952 P21439 BC020618 AAH20618 BC042531 AAH42531 M23234 AAA36207 X06181 CAA29547 Z35284 CAA84542 XM_011516308 XP_011514610 XM_011516309 XP_011514611 XM_011516310 XP_011514612 XM_011516311 XP_011514613 XM_011516312 XP_011514614 XM_011516313 XP_011514615 XM_011516314 XP_011514616 XM_011516315 XP_011514617 XR_927478 NM_000443 NP_000434 NM_018849 NP_061337 NM_018850 NP_061338
Function Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Top Pathways ABC transporters, Bile secretion

Mdr-3 (P3II-26) - sc-58221 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal

Anti-ABCB4 antibody - ab71792 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ABCB4 antibody (ab71792) at 1/100 dilution + Mouse heart tissue lysates at 12.5 µgSecondaryHRP-anti-rabbit

Anti-ABCB4 antibody - ab111209 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab111209, at 3.75 µg/ml, staining ABCB4 in formalin fixed, paraffin embedded Human liver tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase streptavidin and chromogen.

Anti-ABCB4 antibody - ab184878 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Paraffin-embedded Human liver tissue labeling ABCB4 with ab184878 at 1/50 dilution.

Anti-ABCB4 antibody [P3II-26] - ab24108 from Abcam

Prices $379.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone P3II-26
Overlay histogram showing HeLa cells stained with ab24108 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab24108, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG2b [PLPV219] (ab91366, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive signal in HeLa cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-ABCB4 antibody - N-terminal - ab191058 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ABCB4 antibody - N-terminal (ab191058) at 0.5 µg/ml + MCF7 cell lysate

Anti-ABCB4 / MDR3 Antibody (aa632-661, AP) - LS-C212558 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB4 / MDR3 Antibody (aa629-692, clone P3II-26) - LS-C122116 from LifeSpan Bioscience

Prices $665.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone P3II-26

Anti-ABCB4 / MDR3 Antibody (aa632-661, APC) - LS-C212562 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB4 / MDR3 Antibody (clone P3II-26) - LS-C134867 from LifeSpan Bioscience

Prices $325.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone P3II-26

Anti-ABCB4 / MDR3 Antibody (aa632-661, FITC) - LS-C212564 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB4 / MDR3 Antibody (aa632-661, Biotin) - LS-C212563 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB4 / MDR3 Antibody (aa632-661, Azide-free, HRP) - LS-C212565 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB4 / MDR3 Antibody (aa632-661, PE) - LS-C212566 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB4 / MDR3 Antibody - LS-C285442 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ABCB4 / MDR3 Antibody (Biotin) - LS-C317105 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ABCB4 / MDR3 Antibody (FITC) - LS-C318753 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ABCB4 / MDR3 Antibody (aa632-661) - LS-C329185 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ABCB4 / MDR3 Antibody (Internal) - LS-C100360 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-ABCB4 / MDR3 Antibody (aa1-20) - LS-C313209 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
WB of ABCB4 / MDR3 antibody. WB: MCF-7 Cell Lysate.

Anti-ABCB4 / MDR3 Antibody (N-Terminus) IHC-plus™ - LS-B4112 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-ABCB4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4112 concentration 3.75 ug/ml.

Anti-ABCB4 / MDR3 Antibody (aa252-301) IHC-plus™ - LS-B5729 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ABCB4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5729 concentration 5 ug/ml.

Anti-ABCB4 / MDR3 Antibody (aa639-654) - LS-C2974 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ABCB4 / MDR3 Antibody (aa629-692) - LS-C16478 from LifeSpan Bioscience

Prices $560.00
Sizes 125 µg
Host Mouse
Clonality Monoclonal

MDR3/ABCB4 Antibody - NBP2-30876 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: MDR3/ABCB4 Antibody [NBP2-30876] - Staining of human liver shows strong positivity in bile canaliculi.
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