| Gene Symbol |
ABCB4
|
| Entrez Gene |
5244
|
| Alt Symbol |
ABC21, GBD1, ICP3, MDR2, MDR2/3, MDR3, PFIC-3, PGY3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATP-binding cassette, sub-family B (MDR/TAP), member 4
|
| Other Description |
ATP-binding cassette sub-family B member 4|P glycoprotein 3/multiple drug resistance 3|P-glycoprotein 3|P-glycoprotein-3/multiple drug resistance-3|multidrug resistance protein 3|multiple drug resistance 3
|
| Swissprots |
D6W5P3 A4D1D3 Q14813 A0A2V7 D6W5P4 A4D1D4 A4D1D5 P21439
|
| Accessions |
AAD05023 ABH04421 ABH04422 ABH04423 ABH04424 ABH04425 ABH04426 ABH04427 ABH04428 ABH04429 ABH04430 ABH04431 ABH04432 ABH04433 ABH04434 ABH04435 ABH04436 ABH04437 ABH04438 ABH04439 ABH04440 ABH04441 ABH04442 ABH04443 ABJ53424 ABM92358 ABW04992 ABW04993 ADR80227 AFO64626 AFO64627 AFO64628 AFO64629 AFO64630 AFO64631 AFO64632 AFO64633 AHA83530 CAA84543 EAL24174 EAL24175 EAL24176 EAW76944 EAW76945 EAW76946 EAW76947 EAW76948 EAW76949 EAW76950 EAW76951 EAW76952 P21439 BC020618 AAH20618 BC042531 AAH42531 M23234 AAA36207 X06181 CAA29547 Z35284 CAA84542 XM_011516308 XP_011514610 XM_011516309 XP_011514611 XM_011516310 XP_011514612 XM_011516311 XP_011514613 XM_011516312 XP_011514614 XM_011516313 XP_011514615 XM_011516314 XP_011514616 XM_011516315 XP_011514617 XR_927478 NM_000443 NP_000434 NM_018849 NP_061337 NM_018850 NP_061338
|
| Function |
Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Top Pathways |
ABC transporters, Bile secretion
|