| Gene Symbol |
PLEKHA7
|
| Entrez Gene |
144100
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pleckstrin homology domain containing, family A member 7
|
| Other Description |
PH domain-containing family A member 7|pleckstrin homology domain containing, family A member 2|pleckstrin homology domain-containing family A member 7
|
| Swissprots |
B4DWC3 B4DK33 Q6IQ23 Q86VZ7
|
| Accessions |
EAW68452 EAW68454 Q6IQ23 AK296371 BAG59045 AK301465 BAG62985 AW135567 BC032761 BC033239 AAH33239 BC041452 AAH41452 BC071599 AAH71599 BX648885 CN293588 XM_006718149 XP_006718212 XM_011519910 XP_011518212 XM_011519911 XP_011518213 XM_011519912 XP_011518214 XM_011519913 XP_011518215 XM_011519914 XP_011518216 XM_011519915 XP_011518217 XM_011519916 XP_011518218 XM_011519917 XP_011518219 XM_011519918 XP_011518220 NM_175058 NP_778228
|
| Function |
Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. {ECO:0000269|PubMed:19041755}.
|
| Subcellular Location |
Cell junction, adherens junction {ECO:0000269|PubMed:19041755}. Cytoplasm {ECO:0000269|PubMed:19041755}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19041755}. Note=Localizes to zonula adherens, recruited via its interaction with CTNND1.
|