Gene Symbol | PLEKHA7 |
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Entrez Gene | 144100 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | pleckstrin homology domain containing, family A member 7 |
Other Description | PH domain-containing family A member 7|pleckstrin homology domain containing, family A member 2|pleckstrin homology domain-containing family A member 7 |
Swissprots | B4DWC3 B4DK33 Q6IQ23 Q86VZ7 |
Accessions | EAW68452 EAW68454 Q6IQ23 AK296371 BAG59045 AK301465 BAG62985 AW135567 BC032761 BC033239 AAH33239 BC041452 AAH41452 BC071599 AAH71599 BX648885 CN293588 XM_006718149 XP_006718212 XM_011519910 XP_011518212 XM_011519911 XP_011518213 XM_011519912 XP_011518214 XM_011519913 XP_011518215 XM_011519914 XP_011518216 XM_011519915 XP_011518217 XM_011519916 XP_011518218 XM_011519917 XP_011518219 XM_011519918 XP_011518220 NM_175058 NP_778228 |
Function | Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site. {ECO:0000269|PubMed:19041755}. |
Subcellular Location | Cell junction, adherens junction {ECO:0000269|PubMed:19041755}. Cytoplasm {ECO:0000269|PubMed:19041755}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19041755}. Note=Localizes to zonula adherens, recruited via its interaction with CTNND1. |
PLEKHA7 CRISPR/Cas9 KO Plasmid (h) - sc-406043 from Santa Cruz Biotechnology
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PLEKHA7 HDR Plasmid (h) - sc-406043-HDR from Santa Cruz Biotechnology
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PLEKHA7 Double Nickase Plasmid (h) - sc-406043-NIC from Santa Cruz Biotechnology
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PLEKHA7 Double Nickase Plasmid (h2) - sc-406043-NIC-2 from Santa Cruz Biotechnology
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PLEKHA7 CRISPR Activation Plasmid (h) - sc-406043-ACT from Santa Cruz Biotechnology
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PLEKHA7 CRISPR Activation Plasmid (h2) - sc-406043-ACT-2 from Santa Cruz Biotechnology
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PLEKHA7 Lentiviral Activation Particles (h) - sc-406043-LAC from Santa Cruz Biotechnology
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PLEKHA7 Lentiviral Activation Particles (h2) - sc-406043-LAC-2 from Santa Cruz Biotechnology
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PLEKHA7 siRNA (h) - sc-96577 from Santa Cruz Biotechnology
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PLEKHA7 shRNA Plasmid (h) - sc-96577-SH from Santa Cruz Biotechnology
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PLEKHA7 shRNA (h) Lentiviral Particles - sc-96577-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU085231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16952 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16952 from Sigma-Aldrich
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PLEKHA7 siRNA (Human) - CRJ5392 from Cohesion Biosciences
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PLEKHA7 CRISPR/Cas9 KO Plasmid (h2) - sc-406043-KO-2 from Santa Cruz Biotechnology
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PLEKHA7 HDR Plasmid (h2) - sc-406043-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PLEKHA7 (NM_175058.4) - SHH377520 from Creative biogene
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Human PLEKHA7 siRNA - orb275893 from Biorbyt
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PLEKHA7 shRNA Plasmid (Human) - CHJ5392 from Cohesion Biosciences
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PLEKHA7 miRNA 3'UTR clone - MiUTR3H-12549 from Creative biogene
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