| Gene Symbol |
NQO1
|
| Entrez Gene |
1728
|
| Alt Symbol |
DHQU, DIA4, DTD, NMOR1, NMORI, QR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NAD(P)H dehydrogenase, quinone 1
|
| Other Description |
DT-diaphorase|NAD(P)H dehydrogenase [quinone] 1|NAD(P)H:Quinone acceptor oxidoreductase type 1|NAD(P)H:menadione oxidoreductase 1|NAD(P)H:quinone oxidoreductase 1|NAD(P)H:quinone oxireductase|azoreductase|diaphorase (NADH/NADPH) (cytochrome b-5 reductase)|diaphorase-4|dioxin-inducible 1|menadione reductase|phylloquinone reductase|quinone reductase 1
|
| Swissprots |
Q86UK1 P15559 B7ZAD1 B4DNM7 B2R5Y9
|
| Accessions |
AAB60701 AAP20940 CBX47453 CBX47454 CBX47455 CBX51347 EAW83282 EAW83283 EAW83284 P15559 AK223050 BAD96770 AK297125 BAG59630 AK297979 BAG60289 AK298896 BAG61007 AK307533 AK309513 AK312368 BAG35286 AK316246 BAH14617 AV729122 BC000906 BC007659 AAH07659 BC107739 AAI07740 BE903613 BM052991 BM452267 BM787983 BM828301 BQ775231 CD014005 DC331440 DQ892892 ABM83818 DQ896139 ABM87138 J03934 AAA59940 NM_000903 NP_000894 NM_001025433 NP_001020604 NM_001025434 NP_001020605 NM_001286137 NP_001273066
|
| Function |
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
|
| Subcellular Location |
Cytoplasm.
|
| Top Pathways |
Ubiquinone and other terpenoid-quinone biosynthesis
|
![Western Blot: NQO1 Overexpression Lysate (Adult Normal) [NBL1-13761] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NQO1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3448_NQO1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13761-img0002.jpg)