| Gene Symbol |
CYP26B1
|
| Entrez Gene |
56603
|
| Alt Symbol |
CYP26A2, P450RAI-2, P450RAI2, RHFCA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 26, subfamily B, polypeptide 1
|
| Other Description |
cytochrome P450 26B1|cytochrome P450 retinoic acid-inactivating 2|cytochrome P450 retinoid metabolizing protein|cytochrome P450, subfamily XXVIB, polypeptide 1|retinoic acid-metabolizing cytochrome
|
| Swissprots |
B7Z2K6 B7Z3B8 E4W5W7 Q9NR63 B2R8M7 B7Z2P4 Q32MC0 Q53TW1 Q9NP41
|
| Accessions |
AAY14690 EAW99761 Q9NR63 AA484668 AF252297 AAF76003 AK294814 BAH11892 AK294933 BAH11930 AK295683 BAH12154 AK313433 BAG36224 AW873673 BC069443 AAH69443 BC109205 AAI09206 CR749631 CAH18425 DC308258 FJ467289 ACR19332 XM_005264433 XP_005264490 XM_011532988 XP_011531290 NM_001277742 NP_001264671 NM_019885 NP_063938
|
| Function |
Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. {ECO:0000269|PubMed:10823918, ECO:0000269|PubMed:22019272}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain, particularly in the cerebellum and pons. {ECO:0000269|PubMed:10823918}.
|
| Top Pathways |
Retinol metabolism
|