CYP26B1

Gene Symbol	CYP26B1
Entrez Gene	56603
Alt Symbol	CYP26A2, P450RAI-2, P450RAI2, RHFCA
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 26, subfamily B, polypeptide 1
Other Description	cytochrome P450 26B1\|cytochrome P450 retinoic acid-inactivating 2\|cytochrome P450 retinoid metabolizing protein\|cytochrome P450, subfamily XXVIB, polypeptide 1\|retinoic acid-metabolizing cytochrome
Swissprots	B7Z2K6 B7Z3B8 E4W5W7 Q9NR63 B2R8M7 B7Z2P4 Q32MC0 Q53TW1 Q9NP41
Accessions	AAY14690 EAW99761 Q9NR63 AA484668 AF252297 AAF76003 AK294814 BAH11892 AK294933 BAH11930 AK295683 BAH12154 AK313433 BAG36224 AW873673 BC069443 AAH69443 BC109205 AAI09206 CR749631 CAH18425 DC308258 FJ467289 ACR19332 XM_005264433 XP_005264490 XM_011532988 XP_011531290 NM_001277742 NP_001264671 NM_019885 NP_063938
Function	Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. {ECO:0000269\|PubMed:10823918, ECO:0000269\|PubMed:22019272}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Highly expressed in brain, particularly in the cerebellum and pons. {ECO:0000269\|PubMed:10823918}.
Top Pathways	Retinol metabolism

CYP26B1 (C-16) - sc-167571 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CYP26B1 (N-13) - sc-167572 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-Cytochrome P450 26B antibody - ab79818 from Abcam

Prices	$380.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical staining of formalin-fixed and paraffin-embedded human brain tissue with ab79818 followed by HRP-conjugated and DAB staining.

Anti-Cytochrome P450 26B antibody - ab113236 from Abcam

Prices	$407.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

ab113236, at 10µg/ml, staining Cytochrome P450 26B in Formalin-fixed, Paraffin-embedded Human Adrenal tissue by Immunohistochemistry.

Anti-Cytochrome P450 26B antibody - ab113640 from Abcam

Prices	$407.00
Sizes	50 µg
Host	Goat
Clonality	Polyclonal

ab113640, at 3.75 µg/ml, staining Cytochrome P450 26B in formalin fixed, paraffin embedded Human small intestine (submucosal plexus) tissue by Immunohistochemistry.

Anti-Cytochrome P450 26B antibody - ab53555 from Abcam

Prices	$370.00
Sizes	200 µl
Host	Goat
Clonality	Polyclonal

ab53555 at 4µg/ml staining Cytochrome P450 26B in Human cerebellum by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Steamed antigen retrieval with Tris/EDTA buffer pH 9 was performed. Antibody was detected by HRP-staining.

Anti-Cytochrome P450 26B antibody - ab57412 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab57412 Cytochrome P450 26B antibody at 1ug/ml.

Anti-Cytochrome P450 26B antibody [EPR13182] - ab182162 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR13182

Flow cytometric analysis of 2% paraformaldehyde-fixed K562 cells labeling Cytochrome P450 26B with ab182162 at 1/120 dilution (red) compared to a Rabbit monoclonal IgG isotype control (green), followed by Goat anti rabbit IgG (FITC) secondary at 1/150 dilution.

Anti-CYP26B1 Antibody IHC-plus™ - LS-B4833 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP26B1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4833 concentration 10 ug/ml.

Anti-CYP26B1 Antibody (Internal) IHC-plus™ - LS-B4934 from LifeSpan Bioscience

Host	Goat
Clonality	Polyclonal

Anti-CYP26B1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4934 concentration 3.75 ug/ml.

Anti-CYP26B1 Antibody (aa131-231) - LS-C307838 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-CYP26B1 Antibody (aa35-84) - LS-C112036 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

CYP26B1 antibody LS-C112036 Western blot of Jurkat lysate.

Anti-CYP26B1 Antibody (C-Terminus) - LS-C112037 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

CYP26B1 antibody LS-C112037 Western blot of ACHN lysate.

Anti-CYP26B1 Antibody (aa1-512) - LS-C314965 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP26B1 Antibody (C-Terminus) - LS-C99805 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin-embedded human brain tissue reacted with CYP26B1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Cytochrome P450 26B1 Antibody - NBP1-87371 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Cytochrome P450 26B1 Antibody - NB100-53810 from Novus Biologicals

Prices	$299.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Immunohistochemistry-Paraffin: Cytochrome P450 26B1 Antibody [NB100-53810] - staining.

Cytochrome P450 26B1 Antibody (1H6) - H00056603-M01 from Novus Biologicals

Prices	$349.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1H6

Cytochrome P450 26B1 Antibody - NBP1-33476 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: Cytochrome P450 26B1 Antibody [NBP1-33476] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE; antibody diluted at 1:1000.

Cytochrome P450 26B1 Antibody - H00056603-A01 from Novus Biologicals

Prices	$269.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: Cytochrome P450 26B1 Antibody [H00056603-A01] - Analysis of CYP26B1 expression in K-562 (Cat # L009V1).

Monoclonal Anti-CYP26B1 antibody produced in mouse - SAB1405188 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	2G7

<B>Immunofluorescence</B><BR/>Monoclonal Anti-CYP26B1: <B>Cat. No. SAB1405188</B>: Antibody concentration: 10 μg/mL using HeLa cell.

Anti-CYP26B1, (N-terminal) antibody produced in rabbit - SAB2106099 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-CYP26B1 (N-Terminal): <B>Cat. No. SAB2106099</B>: CYP26B1 in Jurkat cell lysates with CYP26B1 antibody at 1.0 μg/mL.

Anti-CYP26B1 antibody produced in rabbit - HPA012567 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-CYP26B1: <B>Cat. No. HPA012567</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver shows cytoplasmic and membranous positivity in hepatocytes.

Monoclonal Anti-CYP26B1 antibody produced in mouse - WH0056603M1 from Sigma-Aldrich

Prices	$347.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	1H6

<B>Immunoblotting</B><BR/>Monoclonal Anti-CYP26B1, <B>Cat. No. WH0056603M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37.11 kDa using immunogen protein lysate.

CYP26B1 antibody - N-terminal region (ARP57351_P050) - ARP57351_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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