| Gene Symbol | ADA |
|---|---|
| Entrez Gene | 100 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | adenosine deaminase |
| Other Description | adenosine aminohydrolase |
| Swissprots | Q6LA59 P00813 Q53F92 |
| Accessions | AAA78791 CAA26130 CBX85542 CBX85614 EAW75904 EAW75905 EAW75906 EAW75907 P00813 AK123988 AK223397 BAD97117 AL832305 BC007678 AAH07678 BC040226 AAH40226 BI601734 DQ892681 ABM83607 DQ895924 ABM86850 KJ534760 AHW56400 S66773 AAB28742 X02994 CAA26734 XM_005260236 XP_005260293 XM_011528478 XP_011526780 XM_011528479 XP_011526781 XR_244129 NM_000022 NP_000013 |
| Function | Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion. {ECO:0000269|PubMed:11772392}. |
| Subcellular Location | Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion. |
| Tissue Specificity | Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues. |
| Top Pathways | Primary immunodeficiency, Purine metabolism |