RACGAP1

Gene Symbol	RACGAP1
Entrez Gene	29127
Alt Symbol	CYK4, HsCYK-4, ID-GAP, MgcRacGAP
Species	Human
Gene Type	protein-coding
Description	Rac GTPase activating protein 1
Other Description	GTPase activating protein|male germ cell RacGap|protein CYK4 homolg|protein CYK4 homolog|rac GTPase-activating protein 1
Swissprots	Q9P2W2 Q9NWN2 Q9H0H5 Q6PJ26 Q9P250
Accessions	EAW58113 EAW58114 EAW58115 Q9H0H5 AB030251 BAA90247 AB040911 BAA96002 AK000733 BAA91347 AK022726 BAB14206 AK225901 AK315785 BAG38131 AL136794 CAB66728 AM393855 CAL38730 BC024144 AAH24144 BC032754 AAH32754 CR533565 CAG38596 DA441098 DB076571 DQ894409 ABM85335 EU176264 ABW03715 XM_005268812 XP_005268869 XM_005268813 XP_005268870 XM_005268814 XP_005268871 XM_005268815 XP_005268872 XM_006719359 XP_006719422 XM_011538235 XP_011536537 XM_011538236 XP_011536538 XM_011538237 XP_011536539 XM_011538238 XP_011536540 XM_011538239 XP_011536541 XM_011538240 XP_011536542 XM_011538241 XP_011536543 XM_011538242 XP_011536544 XM_011538243 XP_011536545 NM_001126103 NP_001119575 NM_001126104 NP_001119576 NM_013277 NP_037409
Function	Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11085985, ECO:0000269|PubMed:11278976
Subcellular Location	Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle, secretory vesicle, acrosome. Cleavage furrow. Midbody. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with RND2 in Golgi- derived proacrosomal vesicles and the acrosome (By similarity). During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase. {ECO:0000250}.
Tissue Specificity	Highly expressed in testis, thymus and placenta. Expressed at lower levels in spleen and peripheral blood lymphocytes. In testis, expression is restricted to germ cells with the highest levels of expression found in spermatocytes. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase. {ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:12590651, ECO:0000269|PubMed:9497316}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RACGAP1 / MGCRACGAP ELISA Kit (Sandwich ELISA) - LS-F7518 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 0.156-10 ng/ml

GTPase Activating Protein, GAP, Human, ELISA Kit - E-EL-H0885 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Rac GTPase-activating protein 1 (RACGAP1), Human, ELISA Kit - CSB-EL019250HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Rac-GTPase Activating Protein 1 (RACGAP1), Human, ELISA Kit - SEE293Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 25.8pg/mL Range 78-5,000pg/mL

Rac-GTPase Activating Protein 1, Ras-GAP1, Human, ELISA Kit - E-EL-H0906 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 46.875 Range 78.125-5000pg/mL

GTPase Activating Protein, GAP, Rabbit, ELISA Kit - E-EL-RB2186 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

GTPase Activating Protein, GAP, Chicken, ELISA Kit - E-EL-Ch0323 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

GTPase Activating Protein, GAP, Porcine, ELISA Kit - E-EL-P0507 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

GTPase Activating Protein, GAP, Sheep, ELISA Kit - E-EL-S0965 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

GTPase Activating Protein, GAP, Guinea Pig, ELISA Kit - E-EL-GP0258 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

GTPase Activating Protein, GAP, Monkey, ELISA Kit - E-EL-MK0517 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

GTPase Activating Protein (Phospho-Ser387) Colorimetric Cell-Based ELISA Kit - CBP1407 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Rac GTPase activating protein 1, ELISA Kit - MBS919252 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human RACGAP1 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 25 pg/ml -1600 pg/ml.

ELISA Kit for Rac-GTPase Activating Protein 1 (RACGAP1) - SEE293Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.056ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Rac GTPase-activating protein 1(RACGAP1) ELISA kit - CSB-EL019250HU from Cusabio Category ELISA Kit Sensitivity 6.25pg/ml Range 25 pg/ml-1600 pg/ml

ELISA Kit for Rac-GTPase Activating Protein 1 (RACGAP1) - SEE293Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.056ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Ras-GAP1(Rac-GTPase Activating Protein 1) ELISA Kit - E-EL-H0906 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 46.88 pg/mLpg/mL Range 78.13~5000 pg/mL

Human RACGAP1 ELISA Kit - abx152914 from Abbexa Category ELISA Kit Sensitivity 0.056 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human RACGAP1 / MGCRACGAP ELISA Kit (Sandwich ELISA) - LS-F23979 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 46.875 pg/ml Range 0.156-10 ng/ml

Human RACGAP1 / MGCRACGAP ELISA Kit (Sandwich ELISA) - LS-F23981 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 46.875 pg/ml Range 0.156-10 ng/ml

Rac-GTPase Activating Protein 1 (RACGAP1), Human, ELISA Kit - DL-RACGAP1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 78-5,000 pg/mL

Human RACGAP1 ELISA Kit - abx576418 from Abbexa Category ELISA Kit Sensitivity 25.8 pg/ml Range 78.125 pg/ml - 5000 pg/ml

Human RACGAP1 ELISA Kit - E032724 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human RACGAP1 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the

RACGAP1 ELISA Kit (Human) (OKCD00426) - OKCD00426 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.056 ng/mL Range 0.156-10 ng/mL

anti-RACGAP1 / MgcRacGAP antibody - ARG63188 from Arigo Biolaboratories Category ELISA Kit

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