SMG8
| Gene Symbol | SMG8 |
|---|---|
| Entrez Gene | 55181 |
| Alt Symbol | C17orf71 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SMG8 nonsense mediated mRNA decay factor |
| Other Description | amplified in breast cancer gene 2 protein|protein SMG8|protein smg-8 homolog|smg-8 homolog, nonsense mediated mRNA decay factor |
| Swissprots | Q8TDN0 Q8ND04 Q9H5P5 Q8N5U5 Q9NVQ1 |
| Accessions | EAW94413 EAW94414 EAW94415 Q8ND04 AF349467 AAL83913 AK001449 BAA91699 AK026858 BAB15576 AL834490 CAD39148 BC020957 AAH20957 BC031604 AAH31604 JF432378 ADZ15595 NM_018149 NP_060619 |
| Function | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. {ECO:0000269|PubMed:19417104}. |
C17orf71 Antibody Blocking Peptide - LS-E20832 from LifeSpan Bioscience
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C17ORF71 Blocking Peptide - 33R-3702 from Fitzgerald
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Recombinant Human Protein SMG8(SMG8) ,partial - CSB-YP818766HU CSB-EP818766HU CSB-BP818766HU CSB-MP818766HU from Cusabio
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ABC2 / SMG8 - TP316692 from Acris Antibodies
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ABC2 Recombinant Protein Antigen - NBP1-87918PEP from Novus Biologicals
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C17orf71-Blocking-Peptide-N-term - BP5399a from Abgent, a WuXi AppTec company
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SMG8 Peptide, Human - M34GP14754H from Creative Peptides
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Protein SMG8 (SMG8), partial, Recombinant Protein - MBS1410419 from MyBioSource
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C17orf71 fusion protein - Ag27820 from Proteintech Group
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