| Gene Symbol |
AGPAT6
|
| Entrez Gene |
137964
|
| Alt Symbol |
1-AGPAT 6, LPAAT-zeta, LPAATZ, TSARG7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
1-acylglycerol-3-phosphate O-acyltransferase 6
|
| Other Description |
1-AGP acyltransferase 6|1-acyl-sn-glycerol-3-phosphate acyltransferase zeta|1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)|glycerol-3-phosphate acyltransferase 6|lysophosphatidic acid acyltransferase zeta|testis spermatogenesis apoptosis-related protein 7
|
| Swissprots |
Q86UL3 Q86V89
|
| Accessions |
CAT16184 EAW63253 EAW63254 EAW63255 Q86UL3 AF317516 AAG33063 AF406612 AAP21893 AL834255 CAD38930 AY358670 AAQ89033 AY513610 AAS82774 BC051377 AAH51377 BC061884 AAH61884 BU620295 DB470455 XM_011544392 XP_011542694 XM_011544393 XP_011542695 XM_011544394 XP_011542696 XM_011544395 XP_011542697 XM_011544396 XP_011542698 XM_011544397 XP_011542699 NM_178819 NP_848934
|
| Function |
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs. {ECO:0000269|PubMed:18238778}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:18238778}; Multi-pass membrane protein {ECO:0000269|PubMed:18238778}.
|
| Tissue Specificity |
Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis. Relatively low level of expression in lung. {ECO:0000269|PubMed:12938015, ECO:0000269|PubMed:18238778}.
|
| Top Pathways |
Glycerolipid metabolism, Glycerophospholipid metabolism
|