Gene Symbol | NSF |
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Entrez Gene | 4905 |
Alt Symbol | SKD2 |
Species | Human |
Gene Type | protein-coding |
Description | N-ethylmaleimide-sensitive factor |
Other Description | N-ethylmaleimide-sensitive factor-like protein|N-ethylmaleimide-sensitive fusion protein|NEM-sensitive fusion protein|vesicle-fusing ATPase|vesicular-fusion protein NSF |
Swissprots | B4DFA2 Q9UKZ2 Q8N6D7 A8K2D9 P46459 |
Accessions | CAH56804 EAW57706 EAW57707 P46459 AF102846 AAF04745 AF135168 AAF70545 AK226078 AK290204 BAF82893 AK294001 BAG57363 AK294727 BAG57874 AK294886 BAG57980 AK299031 BAH12933 AK299786 BAG61667 AK316057 BAH14428 AL049276 BC013314 AAH13314 BC030613 AAH30613 BM451383 DB460965 U03985 AAA17411 U80997 AAG23890 XM_011524863 XP_011523165 XM_011546358 XP_011544660 XM_011547488 XP_011545790 NM_006178 NP_006169 NR_040116 |
Function | Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. |
Top Pathways | Vasopressin-regulated water reabsorption, Synaptic vesicle cycle, GABAergic synapse |
NSF CRISPR/Cas9 KO Plasmid (h) - sc-402258 from Santa Cruz Biotechnology
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NSF HDR Plasmid (h) - sc-402258-HDR from Santa Cruz Biotechnology
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NSF Double Nickase Plasmid (h) - sc-402258-NIC from Santa Cruz Biotechnology
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NSF Double Nickase Plasmid (h2) - sc-402258-NIC-2 from Santa Cruz Biotechnology
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NSF CRISPR Activation Plasmid (h) - sc-402258-ACT from Santa Cruz Biotechnology
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NSF CRISPR Activation Plasmid (h2) - sc-402258-ACT-2 from Santa Cruz Biotechnology
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NSF Lentiviral Activation Particles (h) - sc-402258-LAC from Santa Cruz Biotechnology
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NSF Lentiviral Activation Particles (h2) - sc-402258-LAC-2 from Santa Cruz Biotechnology
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NSF siRNA (h) - sc-36101 from Santa Cruz Biotechnology
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NSF shRNA Plasmid (h) - sc-36101-SH from Santa Cruz Biotechnology
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NSF shRNA (h) Lentiviral Particles - sc-36101-V from Santa Cruz Biotechnology
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NSF RNAi - H00004905-R01 from Novus Biologicals
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MISSION® esiRNA - EHU051331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15530 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15530 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10049 from Sigma-Aldrich
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NSF siRNA (Human) - CRH3260 from Cohesion Biosciences
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shRNA set against Human NSF (NM_006178.3) - SHH355332 from Creative biogene
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Human NSF siRNA - orb263762 from Biorbyt
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NSF shRNA Plasmid (Human) - CHH3260 from Cohesion Biosciences
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NSF miRNA 3'UTR clone - MiUTR3H-04271 from Creative biogene
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