| Gene Symbol |
GLYR1
|
| Entrez Gene |
84656
|
| Alt Symbol |
BM045, HIBDL, N-PAC, NP60
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glyoxylate reductase 1 homolog (Arabidopsis)
|
| Other Description |
3-hydroxyisobutyrate dehydrogenase-like protein|cytokine-like nuclear factor n-pac|nuclear protein 60 kDa|nuclear protein 60kDa|nuclear protein NP60|nuclear protein of 60 kDa|putative oxidoreductase GLYR1
|
| Swissprots |
Q6P1Q2 B4DL47 Q9BXK2 C9JJ60 Q49A26 C9JJ40 Q6V3W7 Q5U632 Q9BTI1
|
| Accessions |
EAW85251 EAW85252 EAW85253 EAW85254 EAW85255 EAW85256 EAW85257 Q49A26 AF217521 AAF67632 AF244907 AAQ14242 AF326966 AAK15524 AK296842 BAG59409 AK307834 AY352585 AAQ57265 BC003693 AAH03693 BC022809 BC032855 AAH32855 BC047223 AAH47223 BC048291 BC063039 BC064940 AAH64940 BC071698 BC073868 CB529066 CK430984 CR933687 DB492328 XM_005255637 XP_005255694 XM_005255638 XP_005255695 XM_005255639 XP_005255696 XM_005255640 XP_005255697 XM_011522716 XP_011521018 XM_011522717 XP_011521019 XM_011522718 XP_011521020 XR_243321 XR_932954 NM_032569 NP_115958
|
| Function |
May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16352664}.
|
![Western Blot: N-PAC Overexpression Lysate (Adult Normal) [NBP2-05994] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for N-PAC.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6367_N-PAC%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05994-img0001.jpg)