| Gene Symbol |
PLXNC1
|
| Entrez Gene |
10154
|
| Alt Symbol |
CD232, PLXN-C1, VESPR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plexin C1
|
| Other Description |
plexin (semaphorin receptor)|plexin-C1|receptor for viral semaphorin protein|receptor for virally-encoded semaphorin|virus-encoded semaphorin protein receptor
|
| Swissprots |
Q59H25 O60486
|
| Accessions |
EAW97500 O60486 AA609130 AB208934 BAD92171 AF030339 AAC18823 AF035307 AK295226 BAG58219 AK304327 BAH14160 AK307920 AK308985 BC029934 BC148590 AAI48591 BC156867 AAI56868 XM_006719186 XP_006719249 XM_011537730 XP_011536032 XM_011537731 XP_011536033 XR_944471 NM_005761 NP_005752 NR_037687
|
| Function |
Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Detected in heart, brain, lung, spleen and placenta. {ECO:0000269|PubMed:9586637}.
|
| Top Pathways |
Axon guidance
|