PDXP

Gene Symbol	PDXP
Entrez Gene	57026
Alt Symbol	CIN, PLP, dJ37E16.5
Species	Human
Gene Type	protein-coding
Description	pyridoxal (pyridoxine, vitamin B6) phosphatase
Other Description	PLP phosphatase|chronophin|pyridoxal phosphate phosphatase
Swissprots	Q9UGY2 Q96GD0
Accessions	EAW60176 EAW60177 Q96GD0 AK057265 AY125047 AAM94358 BC000320 AAH00320 BC009756 AAH09756 BC012832 BC018844 BC064922 AAH64922 NM_020315 NP_064711
Function	Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.
Tissue Specificity	Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.
Top Pathways	Vitamin B6 metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PDXP / Pyridoxal Phosphatase ELISA Kit (Sandwich ELISA) - LS-F12354 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.625 Range 0.625-40 ng/ml

Human PDXP ELISA Kit - abx054750 from Abbexa Category ELISA Kit

Pyridoxal phosphate phosphatase, PDXP, Human, ELISA Kit - E1712h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.625-40 ng/mL

Human PDXP ELISA Kit - HP0640 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PDXP ELISA Kit - AP0640 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Pyridoxal /pyridoxine vitamin B6 -phosphatase, ELISA Kit - MBS731655 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Pyridoxal /Pyridoxine Vitamin B6 -Phosphatase, ELISA Kit - MBS043282 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /pyridoxine vitamin B6 -phosphatase, ELISA Kit - MBS721179 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /Pyridoxine Vitamin B6 -Phosphatase, ELISA Kit - MBS101419 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /Pyridoxine Vitamin B6 -Phosphatase, ELISA Kit - MBS047660 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /Pyridoxine Vitamin B6 -Phosphatase, ELISA Kit - MBS083502 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /pyridoxine vitamin B6 -phosphatase, ELISA Kit - MBS749361 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /pyridoxine vitamin B6 -phosphatase, ELISA Kit - MBS745023 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /Pyridoxine Vitamin B6 -Phosphatase, ELISA Kit - MBS035648 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /pyridoxine vitamin B6 -phosphatase, ELISA Kit - MBS728399 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /Pyridoxine Vitamin B6 -Phosphatase, ELISA Kit - MBS040299 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /Pyridoxine Vitamin B6 -Phosphatase, ELISA Kit - MBS008044 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /Pyridoxine Vitamin B6 -Phosphatase, ELISA Kit - MBS019058 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /Pyridoxine Vitamin B6 -Phosphatase, ELISA Kit - MBS031609 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /Pyridoxine Vitamin B6 -Phosphatase, ELISA Kit - MBS027778 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /pyridoxine vitamin B6 -phosphatase - MBS751234 from MyBioSource Category ELISA Kit Prices $470.00, $675.00 Sizes 48 strip wells, 96 strip wells

Pyridoxal /Pyridoxine Vitamin B6 -Phosphatase, ELISA Kit - MBS026761 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /pyridoxine vitamin B6 -phosphatase, ELISA Kit - MBS745099 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /Pyridoxine Vitamin B6 -Phosphatase, ELISA Kit - MBS060309 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyridoxal /pyridoxine vitamin B6 -phosphatase, ELISA Kit - MBS754075 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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