PDXP

Gene Symbol	PDXP
Entrez Gene	57026
Alt Symbol	CIN, PLP, dJ37E16.5
Species	Human
Gene Type	protein-coding
Description	pyridoxal (pyridoxine, vitamin B6) phosphatase
Other Description	PLP phosphatase|chronophin|pyridoxal phosphate phosphatase
Swissprots	Q9UGY2 Q96GD0
Accessions	EAW60176 EAW60177 Q96GD0 AK057265 AY125047 AAM94358 BC000320 AAH00320 BC009756 AAH09756 BC012832 BC018844 BC064922 AAH64922 NM_020315 NP_064711
Function	Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.
Tissue Specificity	Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.
Top Pathways	Vitamin B6 metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PDXP full length protein - ab97953 from Abcam Category Protein Source E. coli Species Human

PDXP / Pyridoxal Phosphatase Antibody Blocking Peptide - LS-E27532 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDXP / Pyridoxal Phosphatase Antibody Blocking Peptide - LS-E20945 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PDXP Protein - NBP1-45304 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

Recombinant Human PDXP Protein - P3407 from Novus Biologicals Category Protein Prices $669.00 Sizes 50 µg Source E. coli Species Human

PDXP-Antibody-N-term-Blocking-Peptide - BP9822a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DENTT/CDA1 blocking peptide - GTX88198-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog

PDXP Protein (OPPA02349) - OPPA02349 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human Pyridoxal Phosphatase protein - orb90213 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

PDXP Blocking Peptide - 33R-2122 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PDXP Peptide - AC21-2354-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PDXP (1-296, His-tag) - AR09590PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

PDXP (1-296, His-tag) - AR09590PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

PDXP - P3407 from Acris Antibodies Category Protein Prices $580.00 Sizes 50 µg Species Human

PDXP, 1-296aa, Human, His tag, E.coli - 01-1899 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

PDXP Peptide - 42-831P from ProSci Category Peptide Species Human, Mouse, Rat

PDXP Human - ENPS-558 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human PEA15 Protein - BP002622-CF65 from Syd Labs Category Protein Prices $126.00, $378.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

PDXP, 1-296aa, Recombinant Protein - GWB-P1386H from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

PDXP Human Protein - GWB-BSP275 from Genway Biotech Category Protein Prices $75.00, $165.00, $6,190.00 Sizes 2 μg, 10 μg, 1000 μg Source Escherichia Coli. Species Human

Recombinant Human PDXP, His-tagged - PDXP-30082TH from Creative Biomart Category Protein Source E. coli

Recombinant Human PDXP, His-tagged - PDXP-2762H from Creative Biomart Category Protein Source E.coli.

PDXP - JNV-885 from Reagent Proteins Category Protein Prices $364.00, $5,334.00 Sizes 10.00 µg, 1 mg Source E.coli

PDXP 1-296aa - CMB-485 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 50.00 µg, 250.00 µg Source E.coli Species Human

Recombinant Human Pyridoxal phosphate phosphatase(PDXP) - CSB-YP839328HU CSB-EP839328HU CSB-BP839328HU CSB-MP839328HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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