Gene Symbol | Relb |
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Entrez Gene | 19698 |
Alt Symbol | shep |
Species | Mouse |
Gene Type | protein-coding |
Description | avian reticuloendotheliosis viral (v-rel) oncogene related B |
Other Description | transcription factor RelB |
Swissprots | Q04863 Q8VE46 |
Accessions | AAB33259 EDL23169 Q04863 AK146932 BAE27543 AK156767 BAE33846 BC019765 AAH19765 BC034523 AAH34523 BC117792 BC117793 AAI17794 DQ020178 AAY44746 DQ020179 AAY44747 DQ020180 AAY44748 DQ020181 AAY44749 M83380 AAA40041 S56076 AAB25493 XM_006539675 XP_006539738 XM_011250459 XP_011248761 XM_011250460 XP_011248762 XM_011250461 XP_011248763 XM_011250462 XP_011248764 NM_001290457 NP_001277386 NM_009046 NP_033072 |
Function | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa- |
Subcellular Location | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with NEK6 in the centrosome. {ECO:0000250}. |
Tissue Specificity | Expressed in intestine, thymus and spleen. Undetectable in liver, bome marrow, kidney and testis. |
Top Pathways | MAPK signaling pathway, Osteoclast differentiation, HTLV-I infection, Epstein-Barr virus infection |
Phospho-RelB (Ser552) (D41B9) XP ® Rabbit mAb (PE Conjugate) - 13567 from Cell Signaling Technology
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Anti-RELB (AB2) antibody produced in rabbit - AV37870 from Sigma-Aldrich
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RELB antibody - middle region (ARP36969_T100) - ARP36969_T100 from Aviva Systems Biology
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RELB antibody - N-terminal region (ARP37870_T100) - ARP37870_T100 from Aviva Systems Biology
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RelB antibody - 70R-32490 from Fitzgerald
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RelB antibody (Ser552) - 70R-37316 from Fitzgerald
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RelB antibody (Ser552) - 70R-32489 from Fitzgerald
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RELB Antibody - abx104605 from Abbexa
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Anti-V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) - 20-4155 from ARP American Research Products
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RELB Antibody - 28-593 from ProSci
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RELB Antibody - 28-749 from ProSci
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RELB Antibody - GWB-A62711 from Genway Biotech
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RELB Antibody - GWB-7908D8 from Genway Biotech
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RELB, Polyclonal Antibody - MBS834926 from MyBioSource
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RELB, Polyclonal Antibody - MBS834948 from MyBioSource
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Polyclonal Antibody to V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB) - PAB826Mu01 from Cloud-clone
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anti-RelB phospho (Ser573) antibody - ARG51741 from Arigo Biolaboratories |
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Anti-RELB (AB1) antibody produced in rabbit - AV36969 from Sigma-Aldrich
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RELB antibody - middle region : Biotin (ARP36969_T100-Biotin) - ARP36969_T100-Biotin from Aviva Systems Biology
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RELB antibody - middle region : FITC (ARP36969_T100-FITC) - ARP36969_T100-FITC from Aviva Systems Biology
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RELB antibody - middle region : HRP (ARP36969_T100-HRP) - ARP36969_T100-HRP from Aviva Systems Biology
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RELB antibody - N-terminal region : Biotin (ARP37870_T100-Biotin) - ARP37870_T100-Biotin from Aviva Systems Biology
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RELB antibody - N-terminal region : FITC (ARP37870_T100-FITC) - ARP37870_T100-FITC from Aviva Systems Biology
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RELB antibody - N-terminal region : HRP (ARP37870_T100-HRP) - ARP37870_T100-HRP from Aviva Systems Biology
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RELB antibody - orb329899 from Biorbyt
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