| Gene Symbol | Relb |
|---|---|
| Entrez Gene | 19698 |
| Alt Symbol | shep |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | avian reticuloendotheliosis viral (v-rel) oncogene related B |
| Other Description | transcription factor RelB |
| Swissprots | Q04863 Q8VE46 |
| Accessions | AAB33259 EDL23169 Q04863 AK146932 BAE27543 AK156767 BAE33846 BC019765 AAH19765 BC034523 AAH34523 BC117792 BC117793 AAI17794 DQ020178 AAY44746 DQ020179 AAY44747 DQ020180 AAY44748 DQ020181 AAY44749 M83380 AAA40041 S56076 AAB25493 XM_006539675 XP_006539738 XM_011250459 XP_011248761 XM_011250460 XP_011248762 XM_011250461 XP_011248763 XM_011250462 XP_011248764 NM_001290457 NP_001277386 NM_009046 NP_033072 |
| Function | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa- |
| Subcellular Location | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with NEK6 in the centrosome. {ECO:0000250}. |
| Tissue Specificity | Expressed in intestine, thymus and spleen. Undetectable in liver, bome marrow, kidney and testis. |
| Top Pathways | MAPK signaling pathway, Osteoclast differentiation, HTLV-I infection, Epstein-Barr virus infection |
RelB CRISPR/Cas9 KO Plasmid (m) - sc-422643 from Santa Cruz Biotechnology
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RelB HDR Plasmid (m) - sc-422643-HDR from Santa Cruz Biotechnology
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RelB Double Nickase Plasmid (m) - sc-422643-NIC from Santa Cruz Biotechnology
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RelB Double Nickase Plasmid (m2) - sc-422643-NIC-2 from Santa Cruz Biotechnology
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RelB CRISPR Activation Plasmid (m) - sc-422643-ACT from Santa Cruz Biotechnology
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RelB CRISPR Activation Plasmid (m2) - sc-422643-ACT-2 from Santa Cruz Biotechnology
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RelB Lentiviral Activation Particles (m) - sc-422643-LAC from Santa Cruz Biotechnology
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RelB Lentiviral Activation Particles (m2) - sc-422643-LAC-2 from Santa Cruz Biotechnology
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RelB siRNA (m) - sc-36403 from Santa Cruz Biotechnology
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RelB shRNA Plasmid (m)-SH - sc-36403-SH from Santa Cruz Biotechnology
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RelB shRNA (m) Lentiviral Particles - sc-36403-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN40073 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40073 from Sigma-Aldrich
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RELB siRNA (Mouse) - CRM3451 from Cohesion Biosciences
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RELB - MBS8215192 from MyBioSource
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Mouse RELB siRNA - orb282927 from Biorbyt
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RELB shRNA Plasmid (Mouse) - CHM3451 from Cohesion Biosciences
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