DNAJA1

Gene Symbol	DNAJA1
Entrez Gene	3301
Alt Symbol	DJ-2, DjA1, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7, hDJ-2
Species	Human
Gene Type	protein-coding
Description	DnaJ (Hsp40) homolog, subfamily A, member 1
Other Description	HSJ-2|dnaJ homolog subfamily A member 1|dnaJ protein homolog 2|heat shock 40 kDa protein 4|heat shock protein J2|heat shock protein, DNAJ-like 2|human DnaJ protein 2|neural precursor cell expressed, developmentally down-regulated 7
Swissprots	Q86TL9 Q5T7Q0 P31689
Accessions	EAW58524 EAW58525 EAW58526 EAW58527 P31689 AJ277242 CAB93148 AK289623 BAF82312 AK298725 BAH12856 AY186741 AAO31694 BC008182 AAH08182 BI462555 BT007292 AAP35956 D13388 BAA02656 DQ891091 ABM82017 EU176556 ABW03357 L08069 AAC37517 NM_001539 NP_001530
Function	Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}.
Subcellular Location	Membrane {ECO:0000305|PubMed:10816573}; Lipid-anchor {ECO:0000305|PubMed:10816573}. Cytoplasm {ECO:0000269|PubMed:10816573}. Microsome {ECO:0000250}. Nucleus {ECO:0000269|PubMed:10816573}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10816573}. Mitochondrion {ECO:0000250}. Note=Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei. {ECO:0000250}.
Tissue Specificity	Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver. {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:15595953}.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HDJ2 full length protein - ab113174 from Abcam Category Protein Source E. coli Species Human

DNAJA1 / HDJ2 Antibody Blocking Peptide - LS-E19659 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNAJA1 / HDJ2 Antibody Blocking Peptide - LS-E8003 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HDJ2 Protein - H00003301-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

Recombinant Bacterial HDJ2 Protein - NBC1-18361 from Novus Biologicals Category Protein Prices $249.00 Sizes 100 µg Source E. coli

DNAJA1-Antibody-Center-Blocking-peptide - BP5849c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Dnaja1 Blocking Peptide - 33R-10076 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DNAJA1 / HDJ2 - H00003301-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DNAJA1 / HDJ2 - H00003301-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DNAJA1 fusion protein - Ag2284 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

DNAJA1 fusion protein - Ag14635 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DnaJ - GWB-7AFEF6 from Genway Biotech Category Protein Prices $210.00, $630.00 Sizes 100 μg, 500 μg

DnaJ Human - GWB-794227 from Genway Biotech Category Protein Prices $75.00, $165.00, $3,230.00 Sizes 5 μg, 25 μg, 1000 μg Species Human

DnaJ E.Coli - GWB-5B9E98 from Genway Biotech Category Protein Prices $75.00, $165.00, $1,195.00 Sizes 20 μg, 100 μg, 1000 μg Species Escherichia coli

Recombinant Human DnaJ (Hsp40) Homolog, Subfamily A, Member 1 - DNAJA1-2131H from Creative Biomart Category Protein Source E. coli.

Recombinant Human DNAJA1 - DNAJA1-29210TH from Creative Biomart Category Protein Source E. coli

Recombinant Human DNAJA1, GST-tagged - DNAJA1-12054H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human DnaJ homolog subfamily A member 1(DNAJA1) - CSB-YP006999HU CSB-EP006999HU CSB-BP006999HU CSB-MP006999HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DNAJA1 / HDJ2 - TP301628 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

E. coli DnaJ (Amino Acids 1-376) - PED33011 from AssayPro Prices $80.00 Sizes 20 µg Source DnaJ, 1-376aa, E.coli, E.coli Species Escherichia coli

HDJ2 Recombinant Protein Antigen - NBP1-88019PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

HDJ2 Blocking Peptide - abx061881 from Abbexa Category Peptide

DNAJA1-Blocking-Peptide-C-term - BP20747c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DNAJA1 Peptide, Human - M34GP04398H from Creative Peptides Category Peptide Source Synthetic. Species Human

HDJ2 Blocking Peptide - CBP7271 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine

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