DNAJA1

Gene Symbol DNAJA1
Entrez Gene 3301
Alt Symbol DJ-2, DjA1, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7, hDJ-2
Species Human
Gene Type protein-coding
Description DnaJ (Hsp40) homolog, subfamily A, member 1
Other Description HSJ-2|dnaJ homolog subfamily A member 1|dnaJ protein homolog 2|heat shock 40 kDa protein 4|heat shock protein J2|heat shock protein, DNAJ-like 2|human DnaJ protein 2|neural precursor cell expressed, developmentally down-regulated 7
Swissprots Q86TL9 Q5T7Q0 P31689
Accessions EAW58524 EAW58525 EAW58526 EAW58527 P31689 AJ277242 CAB93148 AK289623 BAF82312 AK298725 BAH12856 AY186741 AAO31694 BC008182 AAH08182 BI462555 BT007292 AAP35956 D13388 BAA02656 DQ891091 ABM82017 EU176556 ABW03357 L08069 AAC37517 NM_001539 NP_001530
Function Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co- chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}.
Subcellular Location Membrane {ECO:0000305|PubMed:10816573}; Lipid-anchor {ECO:0000305|PubMed:10816573}. Cytoplasm {ECO:0000269|PubMed:10816573}. Microsome {ECO:0000250}. Nucleus {ECO:0000269|PubMed:10816573}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10816573}. Mitochondrion {ECO:0000250}. Note=Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei. {ECO:0000250}.
Tissue Specificity Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver. {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:15595953}.
Top Pathways Protein processing in endoplasmic reticulum

HSP 40-4 CRISPR/Cas9 KO Plasmid (h) - sc-403819 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 40-4 HDR Plasmid (h) - sc-403819-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 40-4 Double Nickase Plasmid (h) - sc-403819-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 40-4 Double Nickase Plasmid (h2) - sc-403819-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 40-4 CRISPR Activation Plasmid (h) - sc-403819-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 40-4 CRISPR Activation Plasmid (h2) - sc-403819-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 40-4 Lentiviral Activation Particles (h) - sc-403819-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 40-4 Lentiviral Activation Particles (h2) - sc-403819-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 40-4 siRNA (h) - sc-60816 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSP 40-4 shRNA Plasmid (h) - sc-60816-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSP 40-4 shRNA (h) Lentiviral Particles - sc-60816-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HDJ2 RNAi - H00003301-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU114481 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7340 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7340 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01291 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01291

DNAJA1 siRNA (Human) - CRH2257 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DNAJA1 - MBS8231466 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HSP 40-4 CRISPR/Cas9 KO Plasmid (h2) - sc-403819-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSP 40-4 HDR Plasmid (h2) - sc-403819-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human DNAJA1 (NM_001539.2) - SHH279213 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human DNAJA1(NM_001539.2) - SHH009353 from Creative biogene

Category siRNA
Species Reactivities Human

DNAJA1 shRNA Plasmid (Human) - CHH2257 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DNAJA1 miRNA 3'UTR clone - MiUTR1H-02904 from Creative biogene

Species Reactivities Human
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