TLR6

Gene Symbol	TLR6
Entrez Gene	10333
Alt Symbol	CD286
Species	Human
Gene Type	protein-coding
Description	toll-like receptor 6
Other Description	-
Swissprots	Q2NKL3 B6CH35 Q9Y2C9 B6RFS4 B6RFS5 B3Y640
Accessions	AAY88753 AAY88754 AAY88755 AAY88756 AAY88757 AAY88758 AAY88759 AAY88760 AAY88761 AAY88762 ABW37063 ABW37064 ABW37065 ABW37066 ABW37067 ABW37068 ABW37069 ABW37070 ABW37071 ABW37072 ABW37073 ABY67113 ABY67114 ABY67115 ABY67116 ABY67117 ABY67118 ABY67119 ABY67120 ABY67121 ABY67122 ABY67123 ABY67124 ABY67125 ABY67126 ABY67127 ABY67128 ABY67129 ABY67130 ABY67131 ABY67132 ABY67133 CCF76955 EAW92902 Q9Y2C9 AB020807 BAA78631 AB445652 BAG55049 AK313618 BAG36380 BC111755 AAI11756 BF512068 DA619469 XM_005262637 XP_005262694 XM_011513612 XP_011511914 XM_011513613 XP_011511915 XM_011513614 XP_011511916 NM_006068 NP_006059
Function	Participates in the innate immune response to Gram- positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage- activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CC
Subcellular Location	Cell membrane {ECO:0000269|PubMed:20037584}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. {ECO:0000269|PubMed:20037584}.
Tissue Specificity	Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.
Top Pathways	Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Phagosome, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TLR6 ELISA Kit (Sandwich ELISA) - LS-F6818 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.124 ng/ml Range 0.313-20 ng/ml

Mouse TLR6 ELISA Kit (Sandwich ELISA) - LS-F9454 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.54 ng/ml Range 0.313-20 ng/ml

Mouse TLR6 ELISA Kit (Sandwich ELISA) - LS-F12780 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.313-20 ng/ml

Soluble Toll-like Receptor 6 (TLR-6), Human, ELISA Kit - CSB-E15888h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Toll Like Receptor 6 (TLR6), Human, ELISA Kit - SEA683Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.112ng/mL Range 0.312-20ng/mL

Toll-like receptor 6, TLR6, Human, ELISA Kit - E0683h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Toll-Like Receptor 6, TLR6, Rat, ELISA Kit - E-EL-R0908 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

TLR-2, ELISA Kit - MBS2510710 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313--20ng/mL

Toll Like Receptor 6 (TLR-6), ELISA Kit - MBS268581 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 20 ng/ml-0.312 ng/ml

Toll Like Receptor 6 (TLR-6), ELISA Kit - MBS266821 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.06 ng/ml. Range 20 ng/ml-0.312 ng/ml

Toll Like Receptor 6 (TLR-6), ELISA Kit - MBS266849 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 20 ng/ml-0.312 ng/ml

Toll Like Receptor 6 (TLR-6), ELISA Kit - MBS265829 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Toll Like Receptor 6 (TLR-6), ELISA Kit - MBS267909 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Toll Like Receptor 6 (TLR-6), ELISA Kit - MBS2601108 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Toll Like Receptor 6 (TLR-6), ELISA Kit - MBS260770 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Toll Like Receptor 6 (TLR-6), ELISA Kit - MBS262310 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Toll Like Receptor 6 (TLR6), ELISA Kit - MBS2018971 from MyBioSource Category ELISA Kit Prices $345.00, $515.00, $695.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.124ng/mL. Range 0.313-20ng/mL

Toll Like Receptor 6 (TLR6), ELISA Kit - MBS2019814 from MyBioSource Category ELISA Kit Prices $350.00, $525.00, $715.00, $2,915.00, $5,315.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.54ng/mL. Range 1.56-100ng/mL

ELISA Kit for Toll Like Receptor 6 (TLR6) - SEA683Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.112ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Toll Like Receptor 6 (TLR6) - SEA683Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.54ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

Human Soluble Toll-like Receptor 6(TLR-6) ELISA Kit - CSB-E15888h from Cusabio Category ELISA Kit Sensitivity Request Information Range Request Information

ELISA Kit for Toll Like Receptor 6 (TLR6) - SEA683Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.112ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Bovine TLR6 ELISA Kit (Custom ELISA) - LS-F15022 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Human TLR6 ELISA Kit (Custom ELISA) - LS-F15023 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

toll-like receptor 6, ELISA Kit - MBS705756 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human (TLR-6) is typically less than 15.6 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 62.5 pg/ml-4000 pg/ml.

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