| Gene Symbol | TLR6 |
|---|---|
| Entrez Gene | 10333 |
| Alt Symbol | CD286 |
| Species | Human |
| Gene Type | protein-coding |
| Description | toll-like receptor 6 |
| Other Description | - |
| Swissprots | Q2NKL3 B6CH35 Q9Y2C9 B6RFS4 B6RFS5 B3Y640 |
| Accessions | AAY88753 AAY88754 AAY88755 AAY88756 AAY88757 AAY88758 AAY88759 AAY88760 AAY88761 AAY88762 ABW37063 ABW37064 ABW37065 ABW37066 ABW37067 ABW37068 ABW37069 ABW37070 ABW37071 ABW37072 ABW37073 ABY67113 ABY67114 ABY67115 ABY67116 ABY67117 ABY67118 ABY67119 ABY67120 ABY67121 ABY67122 ABY67123 ABY67124 ABY67125 ABY67126 ABY67127 ABY67128 ABY67129 ABY67130 ABY67131 ABY67132 ABY67133 CCF76955 EAW92902 Q9Y2C9 AB020807 BAA78631 AB445652 BAG55049 AK313618 BAG36380 BC111755 AAI11756 BF512068 DA619469 XM_005262637 XP_005262694 XM_011513612 XP_011511914 XM_011513613 XP_011511915 XM_011513614 XP_011511916 NM_006068 NP_006059 |
| Function | Participates in the innate immune response to Gram- positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage- activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CC |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:20037584}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. {ECO:0000269|PubMed:20037584}. |
| Tissue Specificity | Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells. |
| Top Pathways | Toll-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Phagosome, Tuberculosis |