ATP5C1
| Gene Symbol | ATP5C1 |
|---|---|
| Entrez Gene | 509 |
| Alt Symbol | ATP5C, ATP5CL1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 |
| Other Description | ATP synthase gamma chain, mitochondrial|ATP synthase subunit gamma, mitochondrial|F-ATPase gamma subunit|mitochondrial ATP synthase, gamma subunit 1 |
| Swissprots | Q6I9V2 Q5VYP3 P36542 A8KA31 Q96AS8 |
| Accessions | BAA03994 BAA03995 EAW86372 EAW86373 P36542 AK292896 BAF85585 AK294061 BAG57407 AK296803 BAG59376 BC000470 AAH00470 BC000931 AAH00931 BC010380 BC013394 AAH13394 BC013865 BC016812 AAH16812 BC020824 AAH20824 BC026049 AAH26049 BQ893894 CR457403 CAG33684 D16562 BAA03996 D16563 BAA03997 HQ448142 ADQ32623 XM_011519490 XP_011517792 NM_001001973 NP_001001973 NM_005174 NP_005165 |
| Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. |
| Subcellular Location | Mitochondrion. Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Tissue Specificity | Isoform Heart is expressed specifically in the heart and skeletal muscle, which require rapid energy supply. Isoform Liver is expressed in the brain, liver and kidney. Isoform Heart and Isoform Liver are expressed in the skin, intestine, stomach and aorta. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Oxidative phosphorylation |
ATP5C1 CRISPR/Cas9 KO Plasmid (h) - sc-409592 from Santa Cruz Biotechnology
|
||||||||
ATP5C1 HDR Plasmid (h) - sc-409592-HDR from Santa Cruz Biotechnology
|
||||||||
ATP5C1 Double Nickase Plasmid (h) - sc-409592-NIC from Santa Cruz Biotechnology
|
||||||||
ATP5C1 Double Nickase Plasmid (h2) - sc-409592-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ATP5C1 CRISPR Activation Plasmid (h) - sc-409592-ACT from Santa Cruz Biotechnology
|
||||||||
ATP5C1 CRISPR Activation Plasmid (h2) - sc-409592-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ATP5C1 Lentiviral Activation Particles (h) - sc-409592-LAC from Santa Cruz Biotechnology
|
||||||||
ATP5C1 Lentiviral Activation Particles (h2) - sc-409592-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ATP5C1 siRNA (h) - sc-90619 from Santa Cruz Biotechnology
|
||||||||
ATP5C1 shRNA Plasmid (h) - sc-90619-SH from Santa Cruz Biotechnology
|
||||||||
ATP5C1 shRNA (h) Lentiviral Particles - sc-90619-V from Santa Cruz Biotechnology
|
||||||||
ATPG RNAi - H00000509-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU116521 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN3696 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3696 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR02716 from Sigma-Aldrich
|
||||||||
ATP5C1 siRNA (Human) - CRH0353 from Cohesion Biosciences
|
||||||||
ATPG RNAi - H00000509-R01 from Novus Biologicals
|
||||||||
ATP5C1 - MBS8228605 from MyBioSource
|
||||||||
shRNA set against Human ATP5C1 (NM_005174.2) - SHH242758 from Creative biogene
|
||||||||
shRNA set against Human ATP5C1(NM_001001973.1) - SHG082037 from Creative biogene
|
||||||||
shRNA set against Human ATP5C1(NM_005174.2) - SHG082153 from Creative biogene
|
||||||||
ATP5C1 shRNA Plasmid (Human) - CHH0353 from Cohesion Biosciences
|
||||||||
ATP5C1 miRNA 3'UTR clone - MiUTR1H-00692 from Creative biogene
|
||||||||
ATP5C1 miRNA 3'UTR clone - MiUTR1H-00693 from Creative biogene
|