Gene Symbol | TMPRSS3 |
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Entrez Gene | 64699 |
Alt Symbol | DFNB10, DFNB8, ECHOS1, TADG12 |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane protease, serine 3 |
Other Description | serine protease TADG-12|transmembrane protease serine 3|tumor-associated differentially-expressed gene 12 protein |
Swissprots | Q6ZMC3 P57727 Q5USC7 D3DSJ6 |
Accessions | EAX09564 EAX09565 EAX09566 EAX09567 EAX09568 P57727 AB038157 BAB20077 AB038158 BAB20078 AB038159 BAB20079 AB038160 BAB20080 AF201380 AAG37012 AF267741 AAL56664 AI251446 AK131212 AK172842 BAD18806 AY358458 AAQ88823 AY633572 AAT66641 BC074846 AAH74846 BC074847 AAH74847 DA643571 DB217517 NM_001256317 NP_001243246 NM_024022 NP_076927 NM_032404 NP_115780 NM_032405 NP_115781 NR_046020 NM_032401 |
Function | Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). {ECO:0000250, ECO:0000269|PubMed:12393794}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12393794}; Single-pass type II membrane protein {ECO:0000269|PubMed:12393794}. |
Tissue Specificity | Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas. |
TMPRSS3 CRISPR/Cas9 KO Plasmid (h) - sc-407332 from Santa Cruz Biotechnology
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TMPRSS3 HDR Plasmid (h) - sc-407332-HDR from Santa Cruz Biotechnology
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TMPRSS3 Double Nickase Plasmid (h) - sc-407332-NIC from Santa Cruz Biotechnology
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TMPRSS3 Double Nickase Plasmid (h2) - sc-407332-NIC-2 from Santa Cruz Biotechnology
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TMPRSS3 CRISPR Activation Plasmid (h) - sc-407332-ACT from Santa Cruz Biotechnology
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TMPRSS3 CRISPR Activation Plasmid (h2) - sc-407332-ACT-2 from Santa Cruz Biotechnology
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TMPRSS3 Lentiviral Activation Particles (h) - sc-407332-LAC from Santa Cruz Biotechnology
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TMPRSS3 Lentiviral Activation Particles (h2) - sc-407332-LAC-2 from Santa Cruz Biotechnology
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TMPRSS3 siRNA (h) - sc-41659 from Santa Cruz Biotechnology
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TMPRSS3 shRNA Plasmid (h) - sc-41659-SH from Santa Cruz Biotechnology
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TMPRSS3 shRNA (h) Lentiviral Particles - sc-41659-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU052701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2492 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2492 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07016 from Sigma-Aldrich
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TMPRSS3 siRNA (Human) - CRJ2051 from Cohesion Biosciences
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TMPRSS3 RNAi - H00064699-R05 from Novus Biologicals
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TMPRSS3 - MBS8201003 from MyBioSource
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shRNA set against Human TMPRSS3 (NM_024022.2) - SHH431476 from Creative biogene
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shRNA set against Human TMPRSS3(NM_032405.1) - SHL082954 from Creative biogene
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TMPRSS3 shRNA Plasmid (Human) - CHJ2051 from Cohesion Biosciences
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TMPRSS3 miRNA 3'UTR clone - MiUTR1H-10577 from Creative biogene
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TMPRSS3 miRNA 3'UTR clone - MiUTR3H-07744 from Creative biogene
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