Gene Symbol | TBL1X |
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Entrez Gene | 6907 |
Alt Symbol | EBI, SMAP55, TBL1 |
Species | Human |
Gene Type | protein-coding |
Description | transducin (beta)-like 1X-linked |
Other Description | F-box-like/WD repeat-containing protein TBL1X|transducin beta-like protein 1X|transducin-beta-like protein 1, X-linked |
Swissprots | A8K044 Q86UY2 O60907 A8K4J7 |
Accessions | EAW98771 EAW98772 O60907 AB209608 BAD92845 AK289409 BAF82098 AK290962 BAF83651 BC020374 BC029394 BC032708 AAH32708 BC052304 AAH52304 Y12781 CAA73319 XM_011545571 XP_011543873 NM_001139466 NP_001132938 NM_001139467 NP_001132939 NM_001139468 NP_001132940 NM_005647 NP_005638 |
Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. {ECO:0000269|PubMed:14980219}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10330347}. |
Top Pathways | Wnt signaling pathway |
TBL1X CRISPR/Cas9 KO Plasmid (h) - sc-403623 from Santa Cruz Biotechnology
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TBL1X HDR Plasmid (h) - sc-403623-HDR from Santa Cruz Biotechnology
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TBL1X Double Nickase Plasmid (h) - sc-403623-NIC from Santa Cruz Biotechnology
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TBL1X Double Nickase Plasmid (h2) - sc-403623-NIC-2 from Santa Cruz Biotechnology
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TBL1X CRISPR Activation Plasmid (h) - sc-403623-ACT from Santa Cruz Biotechnology
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TBL1X CRISPR Activation Plasmid (h2) - sc-403623-ACT-2 from Santa Cruz Biotechnology
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TBL1X Lentiviral Activation Particles (h) - sc-403623-LAC from Santa Cruz Biotechnology
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TBL1X Lentiviral Activation Particles (h2) - sc-403623-LAC-2 from Santa Cruz Biotechnology
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TBL1X siRNA (h) - sc-38888 from Santa Cruz Biotechnology
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TBL1X shRNA Plasmid (h) - sc-38888-SH from Santa Cruz Biotechnology
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TBL1X shRNA (h) Lentiviral Particles - sc-38888-V from Santa Cruz Biotechnology
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TBL1 RNAi - H00006907-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN21092 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21092 from Sigma-Aldrich
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TBL1X siRNA (Human) - CRH4733 from Cohesion Biosciences
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TBL1X - MBS8205203 from MyBioSource
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Human TBL1X siRNA - orb265235 from Biorbyt
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TBL1X shRNA Plasmid (Human) - CHH4733 from Cohesion Biosciences
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