| Gene Symbol |
Tnf
|
| Entrez Gene |
24835
|
| Alt Symbol |
RATTNF, TNF-alpha, Tnfa
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
tumor necrosis factor
|
| Other Description |
cachectin|tumor necrosis factor (TNF superfamily, member 2)|tumor necrosis factor alpha|tumor necrosis factor ligand superfamily member 2
|
| Swissprots |
Q6EE11 Q9JI27 P16599 Q9JI26
|
| Accessions |
AAA16275 AAA42255 AAK53568 AAK53569 AAK53570 AAK53571 AAK53572 AAK53573 AAR91624 AAR91625 AAR91626 BAA00367 CAE84003 EDL83547 EDL83548 P16599 AF269159 AAF82567 AF269160 AAF82568 AJ002278 CAA05290 BC107671 AAI07672 X66539 CAA47146 NM_012675 NP_036807
|
| Function |
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
|
| Subcellular Location |
C-domain 2: Secreted {ECO:0000250}.
|
| Top Pathways |
Rheumatoid arthritis, Inflammatory bowel disease (IBD), Sphingolipid signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Cytokine-cytokine receptor interaction
|