ABL2

Gene Symbol	ABL2
Entrez Gene	27
Alt Symbol	ABLL, ARG
Species	Human
Gene Type	protein-coding
Description	ABL proto-oncogene 2, non-receptor tyrosine kinase
Other Description	Abelson tyrosine-protein kinase 2|abelson-related gene protein|c-abl oncogene 2, non-receptor tyrosine kinase|tyrosine-protein kinase ARG|v-abl Abelson murine leukemia viral oncogene homolog 2
Swissprots	B7UEF4 Q5T0X6 A0M8X0 Q5W0C5 P42684 B7UEF5 Q6NZY6 Q7Z301 B7UEF3 B7UEF2
Accessions	AAY16984 EAW91040 EAW91041 P42684 AK025877 AK056280 AK225255 AK309549 AK311045 BC065912 AAH65912 BQ014912 BX538317 CAD98092 DA596675 DB280398 FJ542283 ACK76601 FJ542284 ACK76602 FJ542285 ACK76603 FJ542286 ACK76604 M35296 AAA35553 XM_005245088 XP_005245145 XR_921764 XR_921765 NM_001136000 NP_001129472 NM_001136001 NP_001129473 NM_001168236 NP_001161708 NM_001168237 NP_001161709 NM_001168238 NP_001161710 NM_001168239 NP_001161711 NM_005158 NP_005149 NM_007314 NP_009298
Function	Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin- bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endo
Subcellular Location	Cytoplasm, cytoskeleton.
Tissue Specificity	Widely expressed.
Top Pathways	ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ABL2 protein fragment - ab51259 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human ABL2 protein fragment - ab157825 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

ABL Antibody Blocking Peptide - LS-E7238 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ABL2 Protein - H00000027-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ABL2 Recombinant Protein - P3834 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

ABL1-Antibody-Blocking-Peptide - BP3018d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ABL2 - H00000027-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ABL2 - H00000027-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ABL2 - P3834 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

ABL2 - P5784 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

ABL2 fusion protein - Ag11860 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

ABL2 fusion protein - ag11771 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ABL2, GST-tagged - ABL2-673H from Creative Biomart Category Protein Source Baculovirus .

Recombinant Human ABL2, His-tagged - ABL2-9250H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human ABL2, His-tagged - ABL2-233H from Creative Biomart Category Protein Source Sf9 insect cells Species Human

Recombinant Human ABL2, His-tagged - ABL2-800H from Creative Biomart Category Protein

Recombinant Human CCL27 (CTACK) (Carrier-free) - 21-7025 from Tonbo Biosciences Category Protein Prices $69.00, $160.00, $559.00, $1,795.00 Sizes 5 µg, 20 µg, 100 µg, 500 µg Source E. coli Species Human

Recombinant Human IL-27 (Carrier-free) - 21-8279 from Tonbo Biosciences Category Protein Prices $79.00, $269.00 Sizes 2 µg, 10 µg Source HEK293 cells Species Human

Arg Protein, active, 10 µg - 14-460 from EMD Millipore Category Protein Prices $318.00 Sizes 10 µg also available in 250 µg size --call for pricing and availability and reference catalog numbe Source expressed in Sf21 cells

Arg Protein, active, human, 10 µg - 14-521 from EMD Millipore Category Protein Prices $318.00 Sizes 10 µg Source Human Arg expressed by baculovirus in Sf21 insect cells. Species Human

Arg Protein, active, 250 µg - 14-460M from EMD Millipore Category Protein Prices $2,544.00 Sizes 250 µg also available in 10 μg size . (cat#14-460) and in bulk (cat# 14-460-K) Source expressed in Sf21 cells

Recombinant Human Abelson tyrosine-protein kinase 2(ABL2) ,partial - CSB-YP001106HU CSB-EP001106HU CSB-BP001106HU CSB-MP001106HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Abelson tyrosine-protein kinase 2(ABL2) ,partial - MBS958991 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ABL2 (transcript variant a) - TP318110 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human sCD27 Ligand (Carrier-free) - 21-7142 from Tonbo Biosciences Category Protein Prices $69.00, $169.00, $280.00, $859.00 Sizes 10 µg, 50 µg, 100 µg, 500 µg Source CHO cells Species Human

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