ABL2

Gene Symbol	ABL2
Entrez Gene	27
Alt Symbol	ABLL, ARG
Species	Human
Gene Type	protein-coding
Description	ABL proto-oncogene 2, non-receptor tyrosine kinase
Other Description	Abelson tyrosine-protein kinase 2|abelson-related gene protein|c-abl oncogene 2, non-receptor tyrosine kinase|tyrosine-protein kinase ARG|v-abl Abelson murine leukemia viral oncogene homolog 2
Swissprots	B7UEF4 Q5T0X6 A0M8X0 Q5W0C5 P42684 B7UEF5 Q6NZY6 Q7Z301 B7UEF3 B7UEF2
Accessions	AAY16984 EAW91040 EAW91041 P42684 AK025877 AK056280 AK225255 AK309549 AK311045 BC065912 AAH65912 BQ014912 BX538317 CAD98092 DA596675 DB280398 FJ542283 ACK76601 FJ542284 ACK76602 FJ542285 ACK76603 FJ542286 ACK76604 M35296 AAA35553 XM_005245088 XP_005245145 XR_921764 XR_921765 NM_001136000 NP_001129472 NM_001136001 NP_001129473 NM_001168236 NP_001161708 NM_001168237 NP_001161709 NM_001168238 NP_001161710 NM_001168239 NP_001161711 NM_005158 NP_005149 NM_007314 NP_009298
Function	Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin- bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endo
Subcellular Location	Cytoplasm, cytoskeleton.
Tissue Specificity	Widely expressed.
Top Pathways	ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Arg CRISPR/Cas9 KO Plasmid (h) - sc-417779 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Arg HDR Plasmid (h) - sc-417779-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Arg Double Nickase Plasmid (h) - sc-417779-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Arg Double Nickase Plasmid (h2) - sc-417779-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Arg CRISPR Activation Plasmid (h) - sc-417779-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Arg CRISPR Activation Plasmid (h2) - sc-417779-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Arg Lentiviral Activation Particles (h) - sc-417779-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Arg Lentiviral Activation Particles (h2) - sc-417779-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Arg siRNA (h) - sc-38945 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Arg shRNA Plasmid (h) - sc-38945-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Arg shRNA (h) Lentiviral Particles - sc-38945-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ABL2 RNAi - H00000027-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ABL2 RNAi - H00000027-R04 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU014941 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0020 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0023 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0022 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0025 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0019 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0024 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0021 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2673 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2673 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

ABL2 siRNA (Human) - CRH0019 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ABL2 RNAi - H00000027-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

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