| Gene Symbol |
EDNRB
|
| Entrez Gene |
1910
|
| Alt Symbol |
ABCDS, ET-B, ET-BR, ETB, ETBR, ETRB, HSCR, HSCR2, WS4A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
endothelin receptor type B
|
| Other Description |
endothelin B receptor|endothelin receptor non-selective type
|
| Swissprots |
Q9UQK3 Q5W0G9 Q8NHM7 A8K3T4 Q9UD23 Q8NHM9 Q8NHM8 Q8NHM6 O15343 A2A2Z8 Q59GB1 P24530
|
| Accessions |
AAB24922 AAD14177 AAS38516 BAA02445 CAD30645 CAD30646 CAD30647 CAD30648 EAW80573 EAW80574 EAW80575 EAW80576 EAW80577 EAW80578 P24530 AB209198 BAD92435 AF114163 AF114164 AF114165 AAD24541 AK290699 BAF83388 AY275463 AAP32295 BC014472 AAH14472 BG436360 BM557607 D90402 BAA14398 H28710 L06623 AAA52342 M74921 AAA58465 S44866 AAB19411 S57283 AAB25531 S75587 AAB33542 X99250 CAA67623 XM_005266275 XP_005266332 XM_011534949 XP_011533251 NM_000115 NP_000106 NM_001122659 NP_001116131 NM_001201397 NP_001188326 NM_003991 NP_003982 NR_047024
|
| Function |
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:7536888}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. {ECO:0000269|PubMed:9284755}.
|
| Top Pathways |
Melanogenesis, Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction
|
![Western Blot: Endothelin B Receptor Overexpression Lysate (Adult Normal) [NBP2-04148] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Endothelin B Receptor.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4178_Endothelin%2520B%2520Receptor%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04148-img0001.jpg)
![Western Blot: Endothelin B Receptor Overexpression Lysate (Adult Normal) [NBP2-11403] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Endothelin B Receptor.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1105_Endothelin%2520B%2520Receptor%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-11403-img0001.jpg)