Gene Symbol | EDNRB |
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Entrez Gene | 1910 |
Alt Symbol | ABCDS, ET-B, ET-BR, ETB, ETBR, ETRB, HSCR, HSCR2, WS4A |
Species | Human |
Gene Type | protein-coding |
Description | endothelin receptor type B |
Other Description | endothelin B receptor|endothelin receptor non-selective type |
Swissprots | Q9UQK3 Q5W0G9 Q8NHM7 A8K3T4 Q9UD23 Q8NHM9 Q8NHM8 Q8NHM6 O15343 A2A2Z8 Q59GB1 P24530 |
Accessions | AAB24922 AAD14177 AAS38516 BAA02445 CAD30645 CAD30646 CAD30647 CAD30648 EAW80573 EAW80574 EAW80575 EAW80576 EAW80577 EAW80578 P24530 AB209198 BAD92435 AF114163 AF114164 AF114165 AAD24541 AK290699 BAF83388 AY275463 AAP32295 BC014472 AAH14472 BG436360 BM557607 D90402 BAA14398 H28710 L06623 AAA52342 M74921 AAA58465 S44866 AAB19411 S57283 AAB25531 S75587 AAB33542 X99250 CAA67623 XM_005266275 XP_005266332 XM_011534949 XP_011533251 NM_000115 NP_000106 NM_001122659 NP_001116131 NM_001201397 NP_001188326 NM_003991 NP_003982 NR_047024 |
Function | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:7536888}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. {ECO:0000269|PubMed:9284755}. |
Top Pathways | Melanogenesis, Calcium signaling pathway, cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction |
ETBR CRISPR/Cas9 KO Plasmid (h) - sc-401804 from Santa Cruz Biotechnology
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ETBR HDR Plasmid (h) - sc-401804-HDR from Santa Cruz Biotechnology
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ETBR Double Nickase Plasmid (h) - sc-401804-NIC from Santa Cruz Biotechnology
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ETBR Double Nickase Plasmid (h2) - sc-401804-NIC-2 from Santa Cruz Biotechnology
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ETBR CRISPR Activation Plasmid (h) - sc-401804-ACT from Santa Cruz Biotechnology
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ETBR CRISPR Activation Plasmid (h2) - sc-401804-ACT-2 from Santa Cruz Biotechnology
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ETBR Lentiviral Activation Particles (h) - sc-401804-LAC from Santa Cruz Biotechnology
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ETBR Lentiviral Activation Particles (h2) - sc-401804-LAC-2 from Santa Cruz Biotechnology
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ETBR siRNA (h) - sc-39962 from Santa Cruz Biotechnology
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ETBR shRNA Plasmid (h) - sc-39962-SH from Santa Cruz Biotechnology
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ETBR shRNA (h) Lentiviral Particles - sc-39962-V from Santa Cruz Biotechnology
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EDNRB/Endothelin R Type B RNAi - H00001910-R03 from Novus Biologicals
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EDNRB/Endothelin R Type B RNAi - H00001910-R04 from Novus Biologicals
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MISSION® esiRNA - EHU070601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7659 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7659 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11710 from Sigma-Aldrich
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EDNRB siRNA (Human) - CRH1329 from Cohesion Biosciences
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EDNRB - MBS8241120 from MyBioSource
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shRNA set against Human EDNRB (NM_000115.3) - SHH283221 from Creative biogene
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Human EDNRB siRNA - orb261831 from Biorbyt
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EDNRB shRNA Plasmid (Human) - CHH1329 from Cohesion Biosciences
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EDNRB miRNA 3'UTR clone - MiUTR3H-00733 from Creative biogene
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