| Gene Symbol |
AKIRIN2
|
| Entrez Gene |
55122
|
| Alt Symbol |
C6orf166, FBI1, dJ486L4.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
akirin 2
|
| Other Description |
akirin-2|fourteen-three-three beta interactant 1
|
| Swissprots |
Q9BQB1 Q53H80
|
| Accessions |
CAH25916 EAW48578 Q53H80 AK001204 BAA91551 AK222701 BAD96421 BC000764 AAH00764 BC003042 AAH03042 BC005051 AAH05051 BM996262 NM_018064 NP_060534
|
| Function |
Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18066067}.
|
| Tissue Specificity |
Widely expressed with the highest expression in peripheral blood leukocytes. {ECO:0000269|PubMed:18066067}.
|