Gene Symbol | AKIRIN2 |
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Entrez Gene | 55122 |
Alt Symbol | C6orf166, FBI1, dJ486L4.2 |
Species | Human |
Gene Type | protein-coding |
Description | akirin 2 |
Other Description | akirin-2|fourteen-three-three beta interactant 1 |
Swissprots | Q9BQB1 Q53H80 |
Accessions | CAH25916 EAW48578 Q53H80 AK001204 BAA91551 AK222701 BAD96421 BC000764 AAH00764 BC003042 AAH03042 BC005051 AAH05051 BM996262 NM_018064 NP_060534 |
Function | Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18066067}. |
Tissue Specificity | Widely expressed with the highest expression in peripheral blood leukocytes. {ECO:0000269|PubMed:18066067}. |
Akirin2 CRISPR/Cas9 KO Plasmid (h) - sc-407625 from Santa Cruz Biotechnology
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Akirin2 HDR Plasmid (h) - sc-407625-HDR from Santa Cruz Biotechnology
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Akirin2 Double Nickase Plasmid (h) - sc-407625-NIC from Santa Cruz Biotechnology
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Akirin2 Double Nickase Plasmid (h2) - sc-407625-NIC-2 from Santa Cruz Biotechnology
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Akirin2 CRISPR Activation Plasmid (h) - sc-407625-ACT from Santa Cruz Biotechnology
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Akirin2 CRISPR Activation Plasmid (h2) - sc-407625-ACT-2 from Santa Cruz Biotechnology
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Akirin2 Lentiviral Activation Particles (h) - sc-407625-LAC from Santa Cruz Biotechnology
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Akirin2 Lentiviral Activation Particles (h2) - sc-407625-LAC-2 from Santa Cruz Biotechnology
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Akirin2 siRNA (h) - sc-95471 from Santa Cruz Biotechnology
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Akirin2 shRNA Plasmid (h) - sc-95471-SH from Santa Cruz Biotechnology
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Akirin2 shRNA (h) Lentiviral Particles - sc-95471-V from Santa Cruz Biotechnology
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Akirin2 RNAi - H00055122-R01 from Novus Biologicals
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MISSION® esiRNA - EHU136031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3019 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3019 from Sigma-Aldrich
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AKIRIN2 siRNA (Human) - CRJ0485 from Cohesion Biosciences
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AKIRIN2 - MBS8214691 from MyBioSource
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shRNA set against Human AKIRIN2 (NM_018064.3) - SHH234386 from Creative biogene
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Human AKIRIN2 siRNA - orb270986 from Biorbyt
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AKIRIN2 shRNA Plasmid (Human) - CHJ0485 from Cohesion Biosciences
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AKIRIN2 miRNA 3'UTR clone - MiUTR3H-13545 from Creative biogene
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