ERO1L

Gene Symbol	ERO1L
Entrez Gene	30001
Alt Symbol	ERO1-L, ERO1-L-alpha, ERO1-alpha, ERO1A, ERO1LA
Species	Human
Gene Type	protein-coding
Description	ERO1-like (S. cerevisiae)
Other Description	ERO1-like protein alpha|endoplasmic oxidoreductin-1-like protein|oxidoreductin-1-L-alpha
Swissprots	Q7LD45 Q9P1Q9 A8MYW1 A8K9X4 Q9UKV6 Q96HE7
Accessions	EAW65646 EAW65647 Q96HE7 AF081886 AAF35260 AF123887 AAF06104 AK024224 AK292839 BAF85528 AY358463 AAQ88828 BC008674 AAH08674 BC012941 AAH12941 BX420309 CR990477 DR006292 GQ129372 ACT64506 GQ129373 ACT64507 HQ448296 ADQ32776 JF432168 ADZ15385 XM_011536684 XP_011534986 NM_014584 NP_055399
Function	Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:10970843, ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:12403808, ECO:0000269|PubMed:18833192, ECO:0000269|PubMed:18971943, ECO:0000269|PubMed:23027870}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Peripheral membrane protein {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Lumenal side {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum.
Tissue Specificity	Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum. {ECO:0000269|PubMed:10818100}.
Top Pathways	Vibrio cholerae infection, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ERO1L-Over-expression-Lysate - LY13429a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

ERO1L 293T Cell Transient Overexpression Lysate(Denatured) - H00030001-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ERO1L overexpression lysate - LY415183 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ERO1L 293 Cell Lysate - 407153 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ERO1L Overexpression Lysate (Native) - NBP2-07312 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Ero1-Lα (h2): 293 Lysate - sc-111121 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

ERO1L Over-expression Lysate Product - GWB-7C4319 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

ERO1L Overexpression Lysate (Denatured) - H00030001-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

ERO1L Overexpression Lysate (Denatured) - H00030001-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human ERO1L Knockdown Stable Cell Line - CSC-DC005061 from Creative biogene Category Cell Line Species Human

Search more