ERO1L

Gene Symbol ERO1L
Entrez Gene 30001
Alt Symbol ERO1-L, ERO1-L-alpha, ERO1-alpha, ERO1A, ERO1LA
Species Human
Gene Type protein-coding
Description ERO1-like (S. cerevisiae)
Other Description ERO1-like protein alpha|endoplasmic oxidoreductin-1-like protein|oxidoreductin-1-L-alpha
Swissprots Q7LD45 Q9P1Q9 A8MYW1 A8K9X4 Q9UKV6 Q96HE7
Accessions EAW65646 EAW65647 Q96HE7 AF081886 AAF35260 AF123887 AAF06104 AK024224 AK292839 BAF85528 AY358463 AAQ88828 BC008674 AAH08674 BC012941 AAH12941 BX420309 CR990477 DR006292 GQ129372 ACT64506 GQ129373 ACT64507 HQ448296 ADQ32776 JF432168 ADZ15385 XM_011536684 XP_011534986 NM_014584 NP_055399
Function Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:10970843, ECO:0000269|PubMed:11707400, ECO:0000269|PubMed:12403808, ECO:0000269|PubMed:18833192, ECO:0000269|PubMed:18971943, ECO:0000269|PubMed:23027870}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Peripheral membrane protein {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Lumenal side {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum.
Tissue Specificity Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum. {ECO:0000269|PubMed:10818100}.
Top Pathways Vibrio cholerae infection, Protein processing in endoplasmic reticulum

Ero1-Lα Antibody - 3264 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, using Ero1-Lα Antibody.

Ero1-Lα (D-7) - sc-365526 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ero1-Lα (D-7): sc-365526. Western blot analysis of Ero1-Lα expression in HeLa (A) and ES-2 (B) whole cell lysates.

Ero1-Lα (E-19) - sc-79941 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Ero1-Lα (H-90) - sc-98354 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ero1-Lα (H-90): sc-98354. Western blot analysis of Ero1-Lα expression in HEK293 (A) and HeLa (B) whole cell lysates.

Ero1-Lα (P-20) - sc-79942 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Ero1-Lα (YW-8) - sc-100805 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Ero1-L (YW-8): sc-100805. Western blot analysis of Ero1-L expression in HeLa (A), OV-90 (B), and ES-2 (C) whole cell lysates.

Anti-ERO1L antibody - ab131126 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human small intestine tissue labelling ERO1L using ab131126 at 5 µg/ml, followed by biotinylated horse anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-ERO1L antibody - ab172522 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-ERO1L antibody (ab172522) at 1 µg/mlLane 1 : Lysate from 293T cells transfected with ERO1LLane 2 : Lysate from non-transfected 293T cellsLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG at 1/2500 dilution

Anti-ERO1L antibody - ab129241 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ERO1L antibody (ab129241) at 1/100 dilution + CEM cell line lysate at 35 µgSecondaryHRP anti-rabbit at 1/10000 dilutiondeveloped using the ECL technique

Anti-ERO1L antibody - ab140110 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ERO1L antibody (ab140110) at 1/1000 dilutionLane 1 : 293T cell lysatesLane 2 : Hela cell lysatesLane 3 : K562 cell lysatesLane 4 : Huamn fetal liver lysate

Anti-ERO1L antibody - ab57177 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ERO1L antibody - ab81959 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ERO1L antibody (ab81959) at 1/1000 dilution + 293T cell lysate

Anti-ERO1L antibody [EPR12474] - ab177156 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12474
All lanes : Anti-ERO1L antibody [EPR12474] (ab177156) at 1/1000 dilutionLane 1 : HepG2 cell lysateLane 2 : 293T cell lysateLane 3 : MCF7 cell lysateLane 4 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-ERO1L antibody [EPR12475(B)] - ab172954 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12475(B)
Western blot analysis on immunoprecipitation pellet from (1) HepG2 cell lysate or (2) 1X PBS (negative control) using ab172954 and HRP-conjugated anti-rabbit IgG preferentially detecting the non-reduced form of rabbit IgG. Note: primary antibody diluted with 1% BSA.

Anti-ERO1A / ERO1L Antibody (N-Terminus) - LS-C65596 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1A / ERO1L Antibody (N-Terminus, DY650) - LS-C141058 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1A / ERO1L Antibody (N-Terminus, Biotin) - LS-C141057 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1A / ERO1L Antibody (N-Terminus, DY488) - LS-C141059 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1A / ERO1L Antibody (N-Terminus, DY550) - LS-C141061 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1A / ERO1L Antibody (N-Terminus, HRP) - LS-C141060 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1A / ERO1L Antibody (N-Terminus) - LS-C49023 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ERO1L Antibody - Detection of ERO1L in Hela cells.

Anti-ERO1A / ERO1L Antibody (aa350-379, APC) - LS-C235049 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1A / ERO1L Antibody (aa350-379, FITC) - LS-C235052 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1A / ERO1L Antibody (aa350-379, AP) - LS-C235050 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERO1A / ERO1L Antibody (aa350-379, PE) - LS-C235053 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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