KCNAB2

Gene Symbol	KCNAB2
Entrez Gene	8514
Alt Symbol	AKR6A5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, KCNA2B, KV-BETA-2
Species	Human
Gene Type	protein-coding
Description	potassium channel, voltage gated subfamily A regulatory beta subunit 2
Other Description	K(+) channel subunit beta-2|K+ channel beta-2 subunit|potassium channel shaker chain beta 2|potassium voltage-gated channel, shaker-related subfamily, beta member 2|voltage-gated potassium channel subunit beta-2
Swissprots	O43659 Q13303 Q2YD85 B0AZR7 A0AVM9 Q99411 Q5TG82 Q6ZNE4 Q5TG83 A8K1A4
Accessions	CAJ58415 CAJ58416 EAW71512 EAW71513 EAW71514 EAW71515 Q13303 AF029749 AAB84170 AF044253 AAB99859 AK124696 BAG54071 AK131252 BAD18431 AK289819 BAF82508 AK290044 BAF82733 AK312395 BAG35312 AK312871 BAG35723 AK315811 BAF98702 AK315858 BAF98749 AW327942 BC110351 AAI10352 BC126424 AAI26425 BC130413 AAI30414 BI907219 CR542264 CAG47060 CR542287 CAG47082 DA340179 HQ258222 ADR82976 U33429 AAC50955 XM_005263513 XP_005263570 XM_005263514 XP_005263571 XM_011542320 XP_011540622 XM_011542321 XP_011540623 XM_011542322 XP_011540624 XM_011542323 XP_011540625 XM_011542324 XP_011540626 NM_001199860 NP_001186789 NM_001199861 NP_001186790 NM_001199862 NP_001186791 NM_001199863 NP_001186792 NM_003636 NP_003627 NM_172130 NP_742128
Function	Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH- dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4- nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:P62483}. Membrane {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:21357749}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P62483}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:11086297}. Cell junction, synapse, synaptosome {ECO:0000269|PubMed:21357749}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P62483}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated. {ECO:0000250|UniProtKB:P62483}.
Tissue Specificity	Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region (PubMed:11086297). Detected in hippocampus (at protein level) (PubMed:21357749). Detected in hippocampus (PubMed:7649300). {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:21357749, ECO:0000269|PubMed:7649300}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KCNAB2 / Kv-Beta-2 Antibody Blocking Peptide - LS-E12611 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNAB2 / Kv-Beta-2 Antibody Blocking Peptide - LS-E12612 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNAB2 / Kv-Beta-2 Antibody Blocking Peptide - LS-E13511 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNAB2 Protein Lysate (APL10987) - APL10987 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Human KCNAB2 protein - orb246375 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

KCNAB2 Blocking Peptide - 33R-4735 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCNAB2 Blocking Peptide - 33R-8858 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCNAB2 Blocking Peptide - 33R-9950 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCNAB2 fusion protein - ag12120 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

KCNAB2 fusion protein - Ag12096 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human KCNAB2, GST-tagged - KCNAB2-232H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant human Voltage-gated potassium channel subunit beta-2 - CSB-YP012014HU CSB-BP012014HU CSB-MP012014HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Voltage-gated potassium channel subunit beta-2 - CSB-EP012014HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Voltage-gated potassium channel subunit beta-2(KCNAB2) - CSB-YP623796HU CSB-EP623796HU CSB-BP623796HU CSB-MP623796HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

KCNAB2 (transcript variant 1) - TP311690 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

KCNAB2 (transcript variant 2) - TP314602 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Voltage-gated potassium channel subunit beta-2(KCNAB2) , Recombinant Protein - MBS1451328 from MyBioSource Category Protein Prices $1,805.00, $1,805.00, $2,270.00, $2,270.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

KvBeta2 Recombinant Protein Antigen - NBP1-89160PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

KCNAB2 Peptide, Human - M34GP07928H from Creative Peptides Category Peptide Source Synthetic. Species Human

KCNAB2 Protein Lysate - orb333595 from Biorbyt Category Protein Prices $400.00 Sizes 200 μg Species Human

Recombinant human Voltage-gated potassium channel subunit beta-2 - AP70462 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

KCNAB2 Recombinant Protein (Human) (OPCA03888) - OPCA03888 from Aviva Systems Biology Category Protein Species Human

Recombinant Human Voltage-gated potassium channel subunit beta-2 (KCNAB2) - RPC21551 from Biomatik Category Protein Prices $187.00, $342.00, $1,692.00 Sizes 50 µg, 100 µg, 1 mg Source E.coli Species Human

Recombinant Human KCNAB2 protein, Myc/DDK-tagged - KCNAB2-21H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human KCNAB2 protein, Myc/DDK-tagged - KCNAB2-22H from Creative Biomart Category Protein Source HEK293 Species Human

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