| Gene Symbol |
KCNAB2
|
| Entrez Gene |
8514
|
| Alt Symbol |
AKR6A5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, KCNA2B, KV-BETA-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, voltage gated subfamily A regulatory beta subunit 2
|
| Other Description |
K(+) channel subunit beta-2|K+ channel beta-2 subunit|potassium channel shaker chain beta 2|potassium voltage-gated channel, shaker-related subfamily, beta member 2|voltage-gated potassium channel subunit beta-2
|
| Swissprots |
O43659 Q13303 Q2YD85 B0AZR7 A0AVM9 Q99411 Q5TG82 Q6ZNE4 Q5TG83 A8K1A4
|
| Accessions |
CAJ58415 CAJ58416 EAW71512 EAW71513 EAW71514 EAW71515 Q13303 AF029749 AAB84170 AF044253 AAB99859 AK124696 BAG54071 AK131252 BAD18431 AK289819 BAF82508 AK290044 BAF82733 AK312395 BAG35312 AK312871 BAG35723 AK315811 BAF98702 AK315858 BAF98749 AW327942 BC110351 AAI10352 BC126424 AAI26425 BC130413 AAI30414 BI907219 CR542264 CAG47060 CR542287 CAG47082 DA340179 HQ258222 ADR82976 U33429 AAC50955 XM_005263513 XP_005263570 XM_005263514 XP_005263571 XM_011542320 XP_011540622 XM_011542321 XP_011540623 XM_011542322 XP_011540624 XM_011542323 XP_011540625 XM_011542324 XP_011540626 NM_001199860 NP_001186789 NM_001199861 NP_001186790 NM_001199862 NP_001186791 NM_001199863 NP_001186792 NM_003636 NP_003627 NM_172130 NP_742128
|
| Function |
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH- dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4- nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:P62483}. Membrane {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:21357749}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P62483}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:11086297}. Cell junction, synapse, synaptosome {ECO:0000269|PubMed:21357749}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P62483}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated. {ECO:0000250|UniProtKB:P62483}.
|
| Tissue Specificity |
Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region (PubMed:11086297). Detected in hippocampus (at protein level) (PubMed:21357749). Detected in hippocampus (PubMed:7649300). {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:21357749, ECO:0000269|PubMed:7649300}.
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