LRPPRC

Gene Symbol LRPPRC
Entrez Gene 10128
Alt Symbol CLONE-23970, GP130, LRP130, LSFC
Species Human
Gene Type protein-coding
Description leucine-rich pentatricopeptide repeat containing
Other Description 130 kDa leucine-rich protein|LRP 130|leucine-rich PPR motif-containing protein, mitochondrial|leucine-rich PPR-motif containing|mitochondrial leucine-rich PPR motif-containing protein
Swissprots Q6ZUD8 Q7Z7A6 A0PJE3 A8K1V1 Q53PC0 Q96D84 P42704 Q53QN7
Accessions AAY24012 AAY24043 ADP90894 ADP90895 ADP90896 ADP90897 ADP90898 ADP90899 ADP90900 ADP90901 ADP90902 ADP90903 ADP90904 ADP90905 ADP90906 ADP90907 ADP90908 ADP90909 ADP90910 ADP90911 ADP90912 ADP90913 ADP90914 ADP90915 ADP90916 ADP90917 ADP90918 ADP90919 ADP90920 ADP90921 ADP90922 ADP90923 ADP90924 ADP90925 ADP90926 ADP90927 ADP90928 ADP90929 ADP90930 ADP90931 ADP90932 ADP90933 EAX00284 P42704 AF052133 AK125781 BAC86287 AK130686 AK290016 BAF82705 AK299869 BAG61722 AK308348 AY289212 AAP41922 BC010282 AAH10282 BC026034 AAH26034 BC038181 BC050311 AAH50311 BC130285 AAI30286 BQ021667 M92439 AAA67549 XM_006711915 XP_006711978 XM_006711916 XP_006711979 XM_011532473 XP_011530775 XM_011532474 XP_011530776 NM_133259 NP_573566
Function May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). {ECO:0000250}.
Subcellular Location Mitochondrion. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus outer membrane. Note=Seems to be predominantly mitochondrial.
Tissue Specificity Expressed ubiquitously. Expression is highest in heart, skeletal muscle, kidney and liver, intermediate in brain, non-mucosal colon, spleen and placenta, and lowest in small intestine, thymus, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:11827465, ECO:0000269|PubMed:15139850}.

LRP130 (F-7) - sc-166178 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LRP130 (F-7): sc-166178. Western blot analysis of LRP130 expression in non-transfected: sc-117752 (A) and mouse LRP130 transfected: sc-121398 (B) 293T whole cell lysates.

LRP130 (G-10) - sc-166177 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LRP130 (G-10): sc-166177. Western blot analysis of LRP130 expression in non-transfected: sc-117752 (A) and mouse LRP130 transfected: sc-121398 (B) 293T whole cell lysates.

LRP130 (C-15) - sc-33268 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LRP130 (H-300) - sc-66844 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LRP130 (H-300): sc-66844. Western blot analysis of LRP130 expression in HeLa whole cell lysate.

LRP130 (M-300) - sc-66845 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LRP130 (M-300): sc-66845. Western blot analysis of LRP130 expression in non-transfected 293T: sc-117752 (A), mouse LRP130 transfected 293T: sc-121398 (B) and HeLa (C) whole cell lysates.

Anti-LRPPRC antibody - ab97505 from Abcam

Prices $385.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LRPPRC antibody (ab97505) at 1/1000 dilutionLane 1 : H1299 whole cell lysateLane 2 : HeLa whole cell lysateLysates/proteins at 30 µg per lane.

Anti-LRPPRC antibody - ab21864 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-LRPPRC antibody (ab21864) at 1/1000 dilutionLane 1 : Total protein extract from E. coli with ~50ng to 100ng of a negative control fusion protein with an irrelevant antigen at 20 ug Lane 2 : Total protein extract from E. coli with ~50ng to 500ng of the antigen fusion protein at 20 ugSecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated at 1/5000 dilution

Anti-LRPPRC antibody - ab80881 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LRPPRC antibody (ab80881) at 1 µg/mlLane 1 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lane 2 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)Lane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-LRPPRC Antibody (aa611-937) - LS-C186078 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded SW480 Xenograft using LRP130 antibody at 1:100 dilution.

Anti-LRPPRC Antibody - LS-C332518 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using LRPPRC antibody.

gp130/CD130 Antibody (28126) [Unconjugated] - MAB228 from Novus Biologicals

Prices $99.00, $269.00, $699.00
Sizes 25 µg, 100 µg, 500 µg
Host Mouse
Clonality Monoclonal
Clone 28126
Recombinant Human Oncostatin M/OSM stimulates proliferation in the TF‑1 human erythroleukemic cell line (orange line), as measured by Resazurin (Catalog # AR002). Proliferation elicited by Recombinant Human Oncostatin M/OSM (0.8 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human gp130 Monoclonal Antibody (Catalog # MAB228). The ND50 is typically 0.04-0.2 µg/mL.

LRPPRC Antibody - NBP1-32744 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LRPPRC Antibody [NBP1-32744] - Sample (30 ug of whole cell lysate) A: H1299 B: HeLa 5% SDS PAGE, antibody diluted at 1:1000.

gp130/CD130 Antibody (28105) [Unconjugated] - MAB628 from Novus Biologicals

Prices $99.00, $269.00, $699.00
Sizes 25 µg, 100 µg, 500 µg
Host Mouse
Clonality Monoclonal
Clone 28105

gp130/CD130 Antibody (29104) - MAB2281 from Novus Biologicals

Prices $99.00, $269.00, $699.00
Sizes 25 µg, 100 µg, 500 µg
Host Mouse
Clonality Monoclonal
Clone 29104

LRPPRC Antibody - NBP2-38300 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LRPPRC Antibody [NBP2-38300] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG. Lane 4: Human Plasma. Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

LRPPRC Antibody - NBP1-83349 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LRPPRC Antibody [NBP1-83349] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

LRPPRC Antibody - NBP2-19373 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LRPPRC Antibody [NBP2-19373] - Sample (30 ug of whole cell lysate) A: HepG2 B: HCT116 5% SDS PAGE gel, diluted at 1:1000.

gp130/CD130 Antibody (28126) [PE] - FAB228P-100 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 28126

gp130/CD130 Antibody (28126) [PE] - FAB228P-025 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 28126

gp130/CD130 Antibody (28126) [Allophycocyanin] - FAB228A-100 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 28126

gp130/CD130 Antibody (28126) [Fluorescein] - FAB228F-100 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 28126

gp130/CD130 Antibody (28126) [Fluorescein] - FAB228F-025 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 28126

gp130/CD130 Antibody (28126) [Allophycocyanin] - FAB228A-025 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 28126

gp130/CD130 Antibody (28126) [Alexa Fluor (R) 700] - FAB228N-100 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 28126

gp130/CD130 Antibody (28126) [PerCP] - FAB228C-100 from Novus Biologicals

Host Mouse
Clonality Monoclonal
Clone 28126
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