Gene Symbol | LRPPRC |
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Entrez Gene | 10128 |
Alt Symbol | CLONE-23970, GP130, LRP130, LSFC |
Species | Human |
Gene Type | protein-coding |
Description | leucine-rich pentatricopeptide repeat containing |
Other Description | 130 kDa leucine-rich protein|LRP 130|leucine-rich PPR motif-containing protein, mitochondrial|leucine-rich PPR-motif containing|mitochondrial leucine-rich PPR motif-containing protein |
Swissprots | Q6ZUD8 Q7Z7A6 A0PJE3 A8K1V1 Q53PC0 Q96D84 P42704 Q53QN7 |
Accessions | AAY24012 AAY24043 ADP90894 ADP90895 ADP90896 ADP90897 ADP90898 ADP90899 ADP90900 ADP90901 ADP90902 ADP90903 ADP90904 ADP90905 ADP90906 ADP90907 ADP90908 ADP90909 ADP90910 ADP90911 ADP90912 ADP90913 ADP90914 ADP90915 ADP90916 ADP90917 ADP90918 ADP90919 ADP90920 ADP90921 ADP90922 ADP90923 ADP90924 ADP90925 ADP90926 ADP90927 ADP90928 ADP90929 ADP90930 ADP90931 ADP90932 ADP90933 EAX00284 P42704 AF052133 AK125781 BAC86287 AK130686 AK290016 BAF82705 AK299869 BAG61722 AK308348 AY289212 AAP41922 BC010282 AAH10282 BC026034 AAH26034 BC038181 BC050311 AAH50311 BC130285 AAI30286 BQ021667 M92439 AAA67549 XM_006711915 XP_006711978 XM_006711916 XP_006711979 XM_011532473 XP_011530775 XM_011532474 XP_011530776 NM_133259 NP_573566 |
Function | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). {ECO:0000250}. |
Subcellular Location | Mitochondrion. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus outer membrane. Note=Seems to be predominantly mitochondrial. |
Tissue Specificity | Expressed ubiquitously. Expression is highest in heart, skeletal muscle, kidney and liver, intermediate in brain, non-mucosal colon, spleen and placenta, and lowest in small intestine, thymus, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:11827465, ECO:0000269|PubMed:15139850}. |
Gp130/IL6ST BioAssay ELISA K, Human - 143856 from USBiological Life Science
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Gp130/IL6ST BioAssay ELISA Kit, Mouse - 143857 from USBiological Life Science
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gp130 (Glucoprotein 130), Human, ELISA Kit - E-EL-H1988 from ARP American Research Products
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Gp130/IL6ST ELISA K, Human, ELISA Kit - PB-0367 from ARP American Research Products
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Glucoprotein 130, gp130, Mouse, ELISA Kit - E-EL-M0560 from ARP American Research Products
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Glucoprotein 130, gp130, Rat, ELISA Kit - E-EL-R0427 from ARP American Research Products
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gp130 (Glucoprotein 130), Rabbit, ELISA Kit - E-EL-RB1340 from ARP American Research Products
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gp130 (Glucoprotein 130), Chicken, ELISA Kit - E-EL-Ch1073 from ARP American Research Products
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gp130 (Glucoprotein 130), Pig, ELISA Kit - E-EL-P0944 from ARP American Research Products
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Glucoprotein 130, gp130, Sheep, ELISA Kit - E-EL-S0559 from ARP American Research Products
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gp130 (Glucoprotein 130), Monkey, ELISA Kit - E-EL-MK0800 from ARP American Research Products
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Human gp130 ELISA Kit - HG0223 from NeoScientific
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Anserine gp130 ELISA Kit - AG0223 from NeoScientific
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Leucine Rich PPR Motif Containing Protein (LRPPRC), ELISA Kit - MBS2025016 from MyBioSource
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leucine-rich PPR-motif containing, ELISA Kit - MBS9335598 from MyBioSource
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ELISA Kit for Leucine Rich PPR Motif Containing Protein (LRPPRC) - SEJ931Hu from Uscn Life Science Inc.
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Human Glucoprotein 130 ELISA - E01G0216 from BlueGene Biotech
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ELISA Kit for Leucine Rich PPR Motif Containing Protein (LRPPRC) - SEJ931Hu from Cloud-clone
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GP130 - ABE-155-01 from Nordic BioSite
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Human LRPPRC ELISA Kit (Sandwich ELISA) - LS-F25567 from LifeSpan Bioscience
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Human Gp130/IL6ST ELISA Kit - EA100242 from Acris Antibodies
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Human gp130 ELISA KIT - orb339795 from Biorbyt
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Human Gp130 ELISA Kit - orb154573 from Biorbyt
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Human gp130 ELISA Kit - abx571975 from Abbexa
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Gp130/IL6ST - EKH0308 from Nordic BioSite
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