| Gene Symbol |
ADRA1A
|
| Entrez Gene |
100009237
|
| Alt Symbol |
-
|
| Species |
Rabbit
|
| Gene Type |
protein-coding
|
| Description |
adrenoceptor alpha 1A
|
| Other Description |
adrenergic, alpha-1A-, receptor|alpha 1A-adrenoreceptor|alpha 1a-adrenoceptor|alpha-1A adrenergic receptor|alpha-1A adrenoceptor|alpha-1A adrenoreceptor|alpha-1A-adrenergic receptor|alpha-1C adrenergic receptor
|
| Swissprots |
O02824
|
| Accessions |
O02824 AF157505 AAF80168 AF157506 AAF80169 S75999 AAD14204 U81982 AAB61334 NM_001082380 NP_001075849
|
| Function |
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Abundant in liver, vas deferens, brain, and aorta, but not in heart.
|
| Top Pathways |
Calcium signaling pathway, Vascular smooth muscle contraction, Salivary secretion, Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway
|