CSNK1G2

Gene Symbol CSNK1G2
Entrez Gene 1455
Alt Symbol CK1g2
Species Human
Gene Type protein-coding
Description casein kinase 1, gamma 2
Other Description CKI-gamma 2|casein kinase 1 isoform gamma-2|casein kinase I isoform gamma-2
Swissprots P78368 Q8WUB1 O00704 B5BU42
Accessions AAC26983 EAW69426 EAW69427 EAW69428 EAW69429 EAW69430 EAW69431 P78368 AB451278 BAG70092 AB451410 BAG70224 AF001177 AAC00212 AY007134 AAG01997 BC018693 AAH18693 BC018699 AAH18699 BC020972 AAH20972 BT009922 AAP88924 CA423327 CR994929 DQ890695 ABM81621 DQ893880 ABM84806 U89896 AAB88627 XM_005259498 XP_005259555 XM_005259499 XP_005259556 XM_005259500 XP_005259557 XM_005259501 XP_005259558 XR_430129 NM_001319 NP_001310
Function Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. {ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15342122, ECO:0000269|PubMed:15917222, ECO:000
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15077195}.
Tissue Specificity Testis.
Top Pathways Hedgehog signaling pathway

casein kinase Iγ2 (C-20) - sc-18497 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
casein kinase Iγ2 (C-20): sc-18497. Western blot analysis of casein kinase Iγ2 expression in non-transfected: sc-117752 (A) and human casein kinase Iγ2 transfected: sc-172788 (B) 293T whole cell lysates.

casein kinase Iγ2 (F-10) - sc-390970 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
casein kinase Iγ2 (F-10): sc-390970. Western blot analysis of casein kinase Iγ2 expression in NTERA-2 cl.D1 (A) and K-562 (B) whole cell lysates.

casein kinase Iγ2 (N-20) - sc-18496 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
casein kinase Iγ2 (N-20): sc-18496. Western blot analysis of casein kinase Iγ2 in NTERA-2 cl.D1 whole cell lysate.

casein kinase Iγ2 (H-40) - sc-292603 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

casein kinase Iγ2 (26-P) - sc-130365 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
casein kinase Iγ2 (26-P): sc-130365. Western blot analysis of casein kinase Iγ2 expression in HeLa nuclear extract.

Anti-Casein Kinase 1 gamma 2 antibody [1A9] - ab180408 from Abcam

Prices $357.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A9
All lanes : Anti-Casein Kinase 1 gamma 2 antibody [1A9] (ab180408) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY controlLane 2 : HEK293T cells transfected with pCMV6-ENTRY Casein Kinase 1 gamma 2 cDNALysates/proteins at 5 µg per lane.

Anti-Casein Kinase 1 gamma 2 antibody - ab64829 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lanes 1 - 2 : Anti-Casein Kinase 1 gamma 2 antibody (ab102554)Lanes 3 - 4 : Anti-Casein Kinase 1 gamma 2 antibody - C-terminal (ab70862)Lanes 5 - 6 : Anti-Casein Kinase 1 gamma 2 antibody (ab64829) at 1/500 dilutionLane 1 : U2OS cells expressing FLAG-tagged CK1G2 plasmidLane 2 : U2OS cells expressing FLAG tag only plasmidLane 3 : U2OS cells expressing FLAG-tagged CK1G2 plasmidLane 4 : U2OS cells expressing FLAG onlyLane 5 : U2OS cells expressing FLAG-tagged CK1G2 plasmidLane 6 : U2OS cells expressing FLAG onlySecondaryLanes 5 - 6 : HRP-conjugated Goat anti-rabbit polyclonal at 1/1000 dilutiondeveloped using the ECL technique

Anti-Casein Kinase 1 gamma 2 antibody - ab126062 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Casein Kinase 1 gamma 2 antibody (ab126062) at 1/500 dilution + A549 cell lysate at 30 µg

Anti-Casein Kinase 1 gamma 2 antibody - ab102554 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Casein Kinase 1 gamma 2 antibody (ab102554) at 1 µg/ml + A549 cell lysate at 10 µg

Anti-Casein Kinase 1 gamma 2 antibody - ab54686 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54686 Casein Kinase 1 gamma 2 antibody at 1ug/ml.

Anti-Casein Kinase 1 gamma 2 antibody - C-terminal - ab70862 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Lanes 1 - 2 : Anti-Casein Kinase 1 gamma 2 antibody (ab102554)Lanes 3 - 4 : Anti-Casein Kinase 1 gamma 2 antibody - C-terminal (ab70862) at 1/200 dilutionLanes 5 - 6 : Anti-Casein Kinase 1 gamma 2 antibody (ab64829) at 1/500 dilutionLane 1 : U2OS cells transfected with a plasmid expressing FLAG-tagged CK1G2Lane 2 : U2OS cells transfected with a plasmid expressing FLAG onlyLane 3 : U2OS cells transfected with a plasmid expressing FLAG-tagged CK1G2Lane 4 : U2OS cells transfected with a plasmid expressing FLAG onlyLane 5 : U2OS cells transfected with a plasmid expressing FLAG-tagged CK1G2Lane 6 : U2OS cells transfected with a plasmid expressing FLAG onlyLysates/proteins at 90 µg per lane.SecondaryHRP- conjugated Goat anti-rabbit polyclonal at 1/10000 dilutiondeveloped using the ECL technique

Anti-Casein kinase I isoforms gamma 1+2+3 (phospho Y263) antibody - ab111431 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111431, at 1/50 dilution, staining Casein kinase I isoforms gamma 1+2+3 in paraffin-embedded Human brain tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-CSNK1G2 Antibody (C-Terminus, AP) - LS-C275941 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1G2 Antibody (C-Terminus, APC) - LS-C275942 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1G2 Antibody (C-Terminus, Biotin) - LS-C275943 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1G2 Antibody (C-Terminus, FITC) - LS-C275944 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1G2 Antibody (aa130-179) - LS-C81681 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
HEPG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.

Anti-CSNK1G2 Antibody (C-Terminus, Azide-free, HRP) - LS-C275945 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1G2 Antibody (C-Terminus, PE) - LS-C275946 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1G2 Antibody - LS-C310016 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1G2 Antibody (aa315-415) - LS-C307108 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CSNK1G2 Antibody (Gly7) - LS-C176788 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of Casein Kinase I2 (G7) pAb in extracts from HeLa cells.

Anti-CSNK1G2 Antibody (C-Terminus) - LS-C327019 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1G2 Antibody (clone 3F4) - LS-C196984 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 3F4
Detection limit for recombinant GST tagged CSNK1G2 is 3 ng/ml as a capture antibody.

Anti-CSNK1G2 Antibody (aa10-59) - LS-C118964 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa/293 cells, using CKI-gamma2 Antibody. The lane on the right is treated with the synthesized peptide.
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