Gene Symbol | AARS2 |
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Entrez Gene | 57505 |
Alt Symbol | AARSL, COXPD8, LKENP, MT-ALARS, MTALARS |
Species | Human |
Gene Type | protein-coding |
Description | alanyl-tRNA synthetase 2, mitochondrial |
Other Description | alanine tRNA ligase 2, mitochondrial (putative)|alanine--tRNA ligase, mitochondrial|alanyl-tRNA synthetase 2, mitochondrial (putative)|alanyl-tRNA synthetase like|probable alanyl-tRNA synthetase, mitochondrial |
Swissprots | Q9ULF0 Q8N198 Q96D02 A2RRN5 Q5JTZ9 |
Accessions | EAX04268 Q5JTZ9 AB033096 BAA86584 AL536467 BC013593 AAH13593 BC021131 BC033169 AAH33169 BC041026 BC128175 AAI28176 BC131728 AAI31729 BF768723 CN343332 XM_005249245 XP_005249302 XM_011514764 XP_011513066 XR_241907 NM_020745 NP_065796 |
Function | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. {ECO:0000255|HAMAP-Rule:MF_03133}. |
Subcellular Location | Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03133, ECO:0000269|PubMed:21549344}. |
Top Pathways | Aminoacyl-tRNA biosynthesis |
AARS2 CRISPR/Cas9 KO Plasmid (h) - sc-410065 from Santa Cruz Biotechnology
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AARS2 HDR Plasmid (h) - sc-410065-HDR from Santa Cruz Biotechnology
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AARS2 Double Nickase Plasmid (h) - sc-410065-NIC from Santa Cruz Biotechnology
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AARS2 Double Nickase Plasmid (h2) - sc-410065-NIC-2 from Santa Cruz Biotechnology
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AARS2 CRISPR Activation Plasmid (h) - sc-410065-ACT from Santa Cruz Biotechnology
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AARS2 CRISPR Activation Plasmid (h2) - sc-410065-ACT-2 from Santa Cruz Biotechnology
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AARS2 Lentiviral Activation Particles (h) - sc-410065-LAC from Santa Cruz Biotechnology
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AARS2 Lentiviral Activation Particles (h2) - sc-410065-LAC-2 from Santa Cruz Biotechnology
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AARS2 siRNA (h) - sc-95483 from Santa Cruz Biotechnology
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AARS2 shRNA Plasmid (h) - sc-95483-SH from Santa Cruz Biotechnology
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AARS2 shRNA (h) Lentiviral Particles - sc-95483-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU155581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2612 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2612 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10357 from Sigma-Aldrich
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AARS2 siRNA (Human) - CRJ1491 from Cohesion Biosciences
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AARS2 - MBS8239575 from MyBioSource
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shRNA set against Human Aars2 (NM_020745.3) - SHH228658 from Creative biogene
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Human AARS2 siRNA - orb271992 from Biorbyt
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AARS2 shRNA Plasmid (Human) - CHJ1491 from Cohesion Biosciences
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AARS2 miRNA 3'UTR clone - MiUTR3H-12264 from Creative biogene
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