| Gene Symbol |
FGFR2
|
| Entrez Gene |
2263
|
| Alt Symbol |
BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fibroblast growth factor receptor 2
|
| Other Description |
BEK fibroblast growth factor receptor|FGF receptor|FGFR2-AHCYL1 fusion kinase protein|bacteria-expressed kinase|hydroxyaryl-protein kinase|keratinocyte growth factor receptor|protein tyrosine kinase, receptor like 14|soluble FGFR4 variant 4
|
| Swissprots |
Q12922 Q9UNS7 Q1KHY5 Q9NZU3 Q14305 Q14718 Q9UQH8 Q9NZU2 Q9UIH4 Q14719 Q96KM0 Q8IXC7 Q9UD01 E9PCR0 Q86YI4 Q9UMC6 Q9UIH8 Q9UM87 Q96KM1 Q9UIH7 Q96KL9 Q9UIH3 Q9UQI0 Q9UQH9 P18443 Q14302 Q9UIH5 Q9UQH7 Q9UIH6 Q14301 Q14304 Q14303 Q14672 Q9UD02 Q96KM2 P21802 Q14300 Q01742 B4DFC2 E7EVR6
|
| Accessions |
AAB19319 AAB19320 AAC41933 AAC41934 AAC41935 AAC41936 AAC41937 AAC41938 AAD14392 AAD31560 AAD31561 AAD31562 AAD31563 AAD31565 AAD31566 AAD31567 AAF43273 AAF43274 AAK94205 AAK94206 AAK94207 AAK94208 AAK94209 AAM74056 ABE96832 CAA76643 CAJ33699 CCQ43115 CCQ43116 EAW49338 EAW49339 EAW49340 EAW49341 EAW49342 EAW49343 EAW49344 EAW49345 EAW49346 EAW49347 EAW49348 EAW49349 EAW49350 EAW49351 EAW49352 EAW49353 EAW49354 EAW49355 EAW49356 EAW49357 EAW49358 EAW49359 EAW49360 P21802 AB030073 BAA89296 AB030074 BAA89297 AB030075 BAA89298 AB030076 BAA89299 AB030077 BAA89300 AB030078 BAA89301 AB084153 BAC45037 AB821309 BAO19692 AK026508 AK294026 BAG57383 AK308621 BC037338 BC039243 AAH39243 BC096749 CB305736 CN345547 CX873387 EF057068 ABO25744 EU826598 ACF47634 EU826599 ACF47635 EU826600 ACF47636 EU826601 ACF47637 HM437239 ADN43070 M55614 AAA61188 M80634 AAA36147 M87770 AAA59470 M87771 AAA59471 M87772 AAA59472 M97193 AAA52449 S41878 AAB19323 U11814 AAA68514 X52832 CAA37014 X56191 CAA39654 Z71929 CAA96492 XM_006717708 XP_006717771 XM_006717709 XP_006717772 XM_006717710 XP_006717773 XM_006717711 XP_006717774 XM_006717712 XP_006717775 XM_006717713 XP_006717776 XM_011539510 XP_011537812 NM_000141 NP_000132 NM_001144913 NP_001138385 NM_001144914 NP_001138386 NM_001144915 NP_001138387 NM_001144916 NP_001138388 NM_001144917 NP_001138389 NM_001144918 NP_001138390 NM_001144919 NP_001138391 NM_022970 NP_075259 NM_023029 NP_075418 NR_073009 NM_022971 NM_022972 NM_022973 NM_022974 NM_022975 NM_022976 NM_023028 NM_023030
|
| Function |
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activatio
|
| Subcellular Location |
Isoform 19: Secreted.
|
| Top Pathways |
Rap1 signaling pathway, Central carbon metabolism in cancer, Signaling pathways regulating pluripotency of stem cells, PI3K-Akt signaling pathway, Endocytosis
|