FGFR2

Gene Symbol FGFR2
Entrez Gene 2263
Alt Symbol BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25
Species Human
Gene Type protein-coding
Description fibroblast growth factor receptor 2
Other Description BEK fibroblast growth factor receptor|FGF receptor|FGFR2-AHCYL1 fusion kinase protein|bacteria-expressed kinase|hydroxyaryl-protein kinase|keratinocyte growth factor receptor|protein tyrosine kinase, receptor like 14|soluble FGFR4 variant 4
Swissprots Q12922 Q9UNS7 Q1KHY5 Q9NZU3 Q14305 Q14718 Q9UQH8 Q9NZU2 Q9UIH4 Q14719 Q96KM0 Q8IXC7 Q9UD01 E9PCR0 Q86YI4 Q9UMC6 Q9UIH8 Q9UM87 Q96KM1 Q9UIH7 Q96KL9 Q9UIH3 Q9UQI0 Q9UQH9 P18443 Q14302 Q9UIH5 Q9UQH7 Q9UIH6 Q14301 Q14304 Q14303 Q14672 Q9UD02 Q96KM2 P21802 Q14300 Q01742 B4DFC2 E7EVR6
Accessions AAB19319 AAB19320 AAC41933 AAC41934 AAC41935 AAC41936 AAC41937 AAC41938 AAD14392 AAD31560 AAD31561 AAD31562 AAD31563 AAD31565 AAD31566 AAD31567 AAF43273 AAF43274 AAK94205 AAK94206 AAK94207 AAK94208 AAK94209 AAM74056 ABE96832 CAA76643 CAJ33699 CCQ43115 CCQ43116 EAW49338 EAW49339 EAW49340 EAW49341 EAW49342 EAW49343 EAW49344 EAW49345 EAW49346 EAW49347 EAW49348 EAW49349 EAW49350 EAW49351 EAW49352 EAW49353 EAW49354 EAW49355 EAW49356 EAW49357 EAW49358 EAW49359 EAW49360 P21802 AB030073 BAA89296 AB030074 BAA89297 AB030075 BAA89298 AB030076 BAA89299 AB030077 BAA89300 AB030078 BAA89301 AB084153 BAC45037 AB821309 BAO19692 AK026508 AK294026 BAG57383 AK308621 BC037338 BC039243 AAH39243 BC096749 CB305736 CN345547 CX873387 EF057068 ABO25744 EU826598 ACF47634 EU826599 ACF47635 EU826600 ACF47636 EU826601 ACF47637 HM437239 ADN43070 M55614 AAA61188 M80634 AAA36147 M87770 AAA59470 M87771 AAA59471 M87772 AAA59472 M97193 AAA52449 S41878 AAB19323 U11814 AAA68514 X52832 CAA37014 X56191 CAA39654 Z71929 CAA96492 XM_006717708 XP_006717771 XM_006717709 XP_006717772 XM_006717710 XP_006717773 XM_006717711 XP_006717774 XM_006717712 XP_006717775 XM_006717713 XP_006717776 XM_011539510 XP_011537812 NM_000141 NP_000132 NM_001144913 NP_001138385 NM_001144914 NP_001138386 NM_001144915 NP_001138387 NM_001144916 NP_001138388 NM_001144917 NP_001138389 NM_001144918 NP_001138390 NM_001144919 NP_001138391 NM_022970 NP_075259 NM_023029 NP_075418 NR_073009 NM_022971 NM_022972 NM_022973 NM_022974 NM_022975 NM_022976 NM_023028 NM_023030
Function Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activatio
Subcellular Location Isoform 19: Secreted.
Top Pathways Rap1 signaling pathway, Central carbon metabolism in cancer, Signaling pathways regulating pluripotency of stem cells, PI3K-Akt signaling pathway, Endocytosis

FGF Receptor 2 (D4H9) Rabbit mAb - 11835 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4H9
Western blot analysis of recombinant FGF Receptor 1, FGF Receptor 2, FGF Receptor 3, and FGF Receptor 4, as indicated, using FGF Receptor 2 (D4H9) Rabbit mAb (upper) or FGF Receptor 1 (D8E4) XP ® Rabbit mAb #9740 (lane 1), FGF Receptor 2 (D4H9) Rabbit mAb (lane 2), FGF Receptor 3 (C51F2) Rabbit mAb #4574 (lane 3), and FGF Receptor 4 (D3B12) XP ® Rabbit mAb #8562 (lane 4) (lower).

FGF Receptor 2 Antibody - 3116 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using FGF Receptor 2 Antibody.

Bek (C-17) - sc-122 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bek (C-17): sc-122. Western blot analysis of Bek transfected (A) and non-transfected control (B) NIH/3T3 whole cell lysates. Cells kindly provided by D. Bottaro.

Bek (H-80) - sc-20735 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bek (H-80): sc-20735. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing cytoplasmic staining of epidermal cells.

Bek (C-8) - sc-6930 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of Bek transfected NIH/3T3 cells (A,B). Antibodies tested include Bek (C-8): sc-6930 (A) and Bek (C-17): sc-122 (B).

Bek (N-20) - sc-31164 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Bek (P-17) - sc-31166 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-FGFR2 antibody - ab10648 from Abcam

Prices $394.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab10648 staining FGFR2 in the epithelium (top) and transition zone (bottom) of Embryonic Mouse eye tissue sections by Immunohistochemistry ((IHC) paraffin-embedded sections). Tissue was fixed, embedded in paraffin and sectioned. Sections were trypsinized for 40 minutes at room temperature in a humidified chamber, washed in PBS, and then incubated for 1 hour with a 0.5% Triton X-100 and 0.3 M glycine in PBS in a humidified chamber. After antigen retrieval, sections were blocked in 0.5% nonfat dry milk, 10% horse serum, and 0.2% Triton X-100 diluted in PBS for 3 hours at room temperature. An Alexa Fluor®568-conjugated Goat anti-rabbit polyclonal was used as the secondary antibody.

Anti-FGFR2 antibody - ab58201 from Abcam

Prices $394.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
FGFR2 antibody (ab58201) used in immunohistochemistry at 5ug/ml on formalin fixed and paraffin embedded human stomach carcinoma tissue.

Anti-FGFR2 antibody - ab10647 from Abcam

Prices $373.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FGFR2 antibody - ab99230 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FGFR2 antibody (ab99230) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 4 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 5 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-FGFR2 antibody - ab5476 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab5476 stained HeLa cells. The cells were 4% formaldehyde fixed for 10 minutes at room temperature and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1hour at room temperature to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab5476 at 5µg/ml) overnight at +4°C. The secondary antibody (pseudo-colored green) was Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed (ab150081) used at a 1/1000 dilution for 1hour at room temperature. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1hour at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-FGFR2 antibody - ab52246 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FGFR2 antibody (ab52246) at 1/300 dilutionLane 1 : A549 cell extract; without peptideLane 2 : A549 cell extract; with peptide

Anti-FGFR2 antibody - ab125496 from Abcam

Prices $370.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-FGFR2 antibody - ab82350 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FGFR2 antibody (ab82350) at 1/50 dilutionLane 1 : 293 cell lysates, nontransfected Lane 2 : 293 cell lysates, transiently transfected with the FGFR2 gene Lysates/proteins at 2 µg per lane.

Anti-FGFR2 antibody - ab77406 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-FGFR2 antibody (ab77406) at 0.3 µg/ml + A549 lysate in RIPA buffer at 35 µg

Anti-FGFR2 antibody [1D3] - ab118410 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D3
All lanes : Anti-FGFR2 antibody [1D3] (ab118410) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control Lane 2 : HEK293T cells transfected with pCMV6-ENTRY FGFR2 cDNA Lysates/proteins at 5 µg per lane.

Anti-FGFR2 antibody [3F8] - ab119237 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F8
All lanes : Anti-FGFR2 antibody [3F8] (ab119237) at 1/500 dilutionLane 1 : Lysate of HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : Lysate of HEK293T cells transfected with pCMV6-ENTRY FGFR2 cDNA.Lysates/proteins at 5 µg per lane.

Anti-FGFR2 antibody [EPR5180] - ab109372 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5180
All lanes : Anti-FGFR2 antibody [EPR5180] (ab109372) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : Jurkat cell lysateLane 3 : HeLa cell lysateLane 4 : K562 cell lysateLane 5 : T47-D cell lysateLysates/proteins at 10 µg per lane.

Anti-FGFR2 antibody [MM0278-6L19] - ab89476 from Abcam

Prices $385.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0278-6L19
ICC/IF image of ab89476 stained HepG2 cells. The cells were 4% formaldehyde (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab89476, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96879 Dylight 488 goat anti-mouse IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-FGFR2 antibody, prediluted - ab27481 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab27481 staining FGFR2 in human SH-SY5Y cells by Flow Cytometry. Cells were fixed with paraformaldehyde and permeabilized. The sample was incubated with the primary antibody (1/200) for 1 hour at 20°C. An Alexa Fluor® 488-conjugated goat anti-rabbit IgG polyclonal (1/1000) was used as the secondary antibody.Gating Strategy: isotype population (shown in white).See Abreview

Anti-FGFR2 antibody - N-terminal - ab75984 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FGFR2 antibody - N-terminal (ab75984) at 1/50 dilution + Hela cells lysate at 35 µg

Anti-FGFR2 / FGF Receptor 2 Antibody (clone 3F8) - LS-C172910 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F8
IHC of paraffin-embedded Human pancreas tissue using anti-FGFR2 mouse monoclonal antibody.

Anti-FGFR2 / FGF Receptor 2 Antibody (aa471-520) IHC-plus™ - LS-B5979 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FGFR2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5979 concentration 5 ug/ml.

Anti-FGFR2 / FGF Receptor 2 Antibody (aa809-821) - LS-C66137 from LifeSpan Bioscience

Prices $445.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
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