| Gene Symbol | SDHAF3 |
|---|---|
| Entrez Gene | 57001 |
| Alt Symbol | ACN9, DC11, Sdh7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | succinate dehydrogenase complex assembly factor 3 |
| Other Description | ACN9 homolog|SDH assembly factor 3|protein ACN9 homolog, mitochondrial|succinate dehydrogenase assembly factor 3, mitochondrial |
| Swissprots | A4D1J3 Q9NRP4 Q75MD6 |
| Accessions | AAS07570 EAL24120 EAW76739 EAW76740 Q9NRP4 AF201933 AAF86869 BC020621 AAH20621 BC022858 AAH22858 BC028409 CD557710 XM_011516415 XP_011514717 NM_020186 NP_064571 |
| Function | Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. {ECO:0000250|UniProtKB:Q04401, ECO:0000250|UniProtKB:Q8SZ16}. |
| Subcellular Location | Mitochondrion matrix {ECO:0000250|UniProtKB:Q04401}. |
ACN9 homolog (S. cerevisiae) , ELISA Kit - MBS9326742 from MyBioSource
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Human ACN9 ELISA Kit - E000337 from Biobool
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Human SDHAF3 ELISA Kit - E097474 from Biobool
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ACN9, ELISA Kit - MBS285136 from MyBioSource
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