| Gene Symbol | ARHGAP10 |
|---|---|
| Entrez Gene | 79658 |
| Alt Symbol | GRAF2, PS-GAP, PSGAP |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rho GTPase activating protein 10 |
| Other Description | GTPase regulator associated with focal adhesion kinase 2|graf-related protein 2|rho GTPase-activating protein 10|rho-type GTPase-activating protein 10 |
| Swissprots | Q96S75 Q96EV3 Q2VPC4 A1A4S6 A1L0S5 Q2VPC5 |
| Accessions | A1A4S6 EAX05009 EAX05010 AB050785 BAB61771 AK024549 BAB14924 AK123034 BAG53857 AK123785 AK130998 AK304458 BAG65274 AL834360 CAD39024 BC011920 AAH11920 BC047914 AAH47914 BC106018 AAI06019 BC109029 AAI09030 BC109030 AAI09031 BC126899 AAI26900 BC128055 AAI28056 BX647727 CR457328 CAG33609 XM_005263215 XP_005263272 XM_005263217 XP_005263274 XM_011532243 XP_011530545 XM_011532244 XP_011530546 NM_024605 NP_078881 |
| Function | GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Association to cell membrane is dependent on PH domain. {ECO:0000250}. |
| Tissue Specificity | High levels of expression in heart and skeletal muscle. {ECO:0000269|PubMed:11432776}. |
| Top Pathways | Bacterial invasion of epithelial cells |