| Gene Symbol |
Prmt7
|
| Entrez Gene |
214572
|
| Alt Symbol |
4933402B05Rik, BC006705
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
protein arginine N-methyltransferase 7
|
| Other Description |
[Myelin basic protein]-arginine N-methyltransferase PRMT7|histone-arginine N-methyltransferase PRMT7
|
| Swissprots |
Q6PG80 Q6B955 Q922X9 Q69Z62 Q3TRZ6
|
| Accessions |
EDL11357 EDL11358 Q922X9 AK040103 AK087254 AK154255 BAE32467 AK162376 BAE36880 AK173304 BAD32582 AK179702 AK182211 AK217843 AY673972 AAT76979 BC006705 AAH06705 BC012845 AAH12845 BC057177 AAH57177 XM_006530828 XP_006530891 NM_145404 NP_663379
|
| Function |
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.
|
![Western Blot: PRMT7 Antibody [NBP1-82409] - Mouse Thymus Lysate 1ug/ml Gel Concentration 12%](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_4/3822_PRMT7-Antibody-Western-Blot-NBP1-82409-img0002.jpg)
