Piwil1

Gene Symbol	Piwil1
Entrez Gene	57749
Alt Symbol	MIWI
Species	Mouse
Gene Type	protein-coding
Description	piwi-like RNA-mediated gene silencing 1
Other Description	piwi like homolog 1|piwi-like homolog 1|piwi-like protein 1
Swissprots	A1L324 Q9JMB7 A1L325 Q6NXX0
Accessions	EDL19532 EDL19533 Q9JMB7 AB032604 BAA93705 AF438405 AAL31014 BC066846 AAH66846 BC129857 AAI29858 BC129858 AAI29859 EF196092 ABM69181 XM_006504318 XP_006504381 XM_006504319 XP_006504382 NM_021311 NP_067286
Function	Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability. {ECO:0000269|PubMed:11578866}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11578866, ECO:0000269|PubMed:12062093, ECO:0000269|PubMed:16787948, ECO:0000269|PubMed:16938833, ECO:0000269|PubMed:19020299, ECO:0000269|PubMed:19584108}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body.
Tissue Specificity	Expressed in brain. Expressed in testis, specifically in spermatocytes (at protein level). Only detected in germ lineage cells of adult testis. Expressed in male gonads 2 weeks after birth at the initiation of spermatogenesis, but not expressed in female gonads. {ECO:0000269|PubMed:11578866, ECO:0000269|PubMed:12062093, ECO:0000269|PubMed:19377467, ECO:0000269|PubMed:19926723}.
Top Pathways	Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Miwi (D92B7) XP ® Rabbit mAb - 6915 from Cell Signaling Technology Prices $277.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D92B7

MIWI antibody - orb192540 from Biorbyt Prices $536.00 Sizes 100 μl Host Rabbit Clonality Polyclonal

Rabbit Anti Mouse PIWIL1 (OACA02340) - OACA02340 from Aviva Systems Biology Prices $340.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti -MIWI (Piwi-like Protein 1, Piwil1, Miwi, PIWIL1) - 212004 from USBiological Life Science Host Rabbit Clonality Polyclonal

PIWIL1 Polyclonal Antibody - A2150 from ABclonal Prices $130.00, $220.00, $380.00 Sizes 50 µl, 100 µl, 200 µl Host Rabbit Clonality Polyclonal

PIWIL1 Antibody - abx117230 from Abbexa Host Rabbit Clonality Polyclonal

Anti-PIWIL1 - 31-B6909 from ARP American Research Products Prices $169.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIWI antibody - STJ70673 from St John's Laboratory Ltd Host Goat Clonality Polyclonal

Anti-MIWI antibody - STJ25007 from St John's Laboratory Ltd Host Rabbit Clonality Polyclonal

PIWIL1 - A2150 from NeoScientific Prices $220.00, $380.00 Sizes 100 µl, 200 µl Host Rabbit Clonality Polyclonal

MIWI Antibody - E92150 from Enogene Prices $255.00 Sizes 100 µl Host Rabbit

MIWI Antibody - E90089 from Enogene Prices $225.00 Sizes 100μg/100μl Host Rabbit

PIWIL1 Polyclonal Antibody - PA5-17036 from Thermo Fisher Scientific Prices $275.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PIWIL1 Polyclonal Antibody - PA5-23438 from Thermo Fisher Scientific Prices $349.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PIWIL1 Polyclonal Antibody - PA5-17030 from Thermo Fisher Scientific Prices $275.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PIWIL1 Polyclonal Antibody - PA5-17034 from Thermo Fisher Scientific Prices $275.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MIWI, Polyclonal Antibody - MBS2516537 from MyBioSource Prices $195.00, $270.00, $435.00 Sizes 60 µl, 120 µl, 200 µl Host Rabbit Clonality Polyclonal

MIWI , Polyclonal Antibody - MBS126629 from MyBioSource Prices $230.00, $305.00, $460.00 Sizes 50 µl, 100 µl, 200 µl Host Rabbit Clonality Polyclonal

MIWI, Polyclonal Antibody - MBS856783 from MyBioSource Prices $290.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PIWIL1 , Polyclonal Antibody - MBS1489076 from MyBioSource Prices $295.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PIWIL1 polyclonal antibody - BS6909 from Bioworld Technology Prices $208.00, $358.00 Sizes 50 µl, 100 µl Host Rabbit Clonality Polyclonal

Piwil1 Antibody - CSB-PA018045KA01HU from Cusabio Host Rabbit

MIWI Antibody - DF6873 from Affinity Biosciences Prices $220.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

MIWI, Polyclonal Antibody - MBS9410143 from MyBioSource Prices $255.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

MIWI antibody - orb136968 from Biorbyt Prices $264.00, $366.00, $519.00 Sizes 50 μg, 100 μg, 200 μg Host Rabbit Clonality Polyclonal

Search more