| Gene Symbol |
Piwil1
|
| Entrez Gene |
57749
|
| Alt Symbol |
MIWI
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
piwi-like RNA-mediated gene silencing 1
|
| Other Description |
piwi like homolog 1|piwi-like homolog 1|piwi-like protein 1
|
| Swissprots |
A1L324 Q9JMB7 A1L325 Q6NXX0
|
| Accessions |
EDL19532 EDL19533 Q9JMB7 AB032604 BAA93705 AF438405 AAL31014 BC066846 AAH66846 BC129857 AAI29858 BC129858 AAI29859 EF196092 ABM69181 XM_006504318 XP_006504381 XM_006504319 XP_006504382 NM_021311 NP_067286
|
| Function |
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability. {ECO:0000269|PubMed:11578866}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11578866, ECO:0000269|PubMed:12062093, ECO:0000269|PubMed:16787948, ECO:0000269|PubMed:16938833, ECO:0000269|PubMed:19020299, ECO:0000269|PubMed:19584108}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body.
|
| Tissue Specificity |
Expressed in brain. Expressed in testis, specifically in spermatocytes (at protein level). Only detected in germ lineage cells of adult testis. Expressed in male gonads 2 weeks after birth at the initiation of spermatogenesis, but not expressed in female gonads. {ECO:0000269|PubMed:11578866, ECO:0000269|PubMed:12062093, ECO:0000269|PubMed:19377467, ECO:0000269|PubMed:19926723}.
|
| Top Pathways |
Dorso-ventral axis formation
|