| Gene Symbol |
MARC1
|
| Entrez Gene |
64757
|
| Alt Symbol |
MOSC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitochondrial amidoxime reducing component 1
|
| Other Description |
MOCO sulphurase C-terminal domain containing 1|MOSC domain-containing protein 1, mitochondrial|mitochondrial amidoxime-reducing component 1|moco sulfurase C-terminal domain-containing protein 1|molybdenum cofactor sulfurase C-terminal domain-containing protein 1
|
| Swissprots |
Q9H6C7 Q5VT66 B2D078 A8K447 Q96FN8 Q5VVS9 Q5VVT0 Q8N9P5 Q5VVT1
|
| Accessions |
ACB21046 EAW93291 Q5VT66 AK000035 AK026043 BAB15333 AK092439 AK094105 BAC04286 AK225416 AK290812 BAF83501 BC010619 AAH10619 CA439234 CB048738 DA878171 XM_011509900 XP_011508202 XM_011509901 XP_011508203 XM_011509902 XP_011508204 XM_011509903 XP_011508205 XM_011509904 XP_011508206 XR_921908 NM_022746 NP_073583
|
| Function |
As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. {ECO:0000269|PubMed:19053771}.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000269|PubMed:23086957}; Single-pass type II membrane protein {ECO:0000269|PubMed:23086957}. Note=Mitochondrial import is mediated by AA 1-40 and requires ATP.
|
![Western Blot: MOSC1 Overexpression Lysate (Adult Normal) [NBL1-13189] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MOSC1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5045_MOSC1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13189-img0002.jpg)